In vivo neurometabolic profiling in orthostatic tremor

Julián Benito-León, Elan D. Louis, Virginia Mato-Abad, Ulrike Dydak, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, José Antonio Molina-Arjona, Norberto Malpica, Michele Matarazzo, Juan Pablo Romero, Álvaro Sánchez-Ferro

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The pathogenesis of orthostatic tremor (OT) remains unclear, although some evidence points to dysfunction in the brainstem or cerebellum. We used single voxel proton magnetic resonance spectroscopy (1H-MRS) (3 T) to investigate whether neurochemical changes underlie abnormal cerebellar or cortical function in OT. Fourteen OT patients and 14 healthy controls underwent 1H-MRS studies with voxels placed in midparietal gray matter and cerebellum (vermis and central white matter). Spectral analysis was analyzed using the software package LCModel (version 6.3). The absolute metabolite concentrations and ratios of total N-acetylaspartate +N-acetylaspartyl glutamate (NAA), choline-containing compounds, myoinositol, and glutamate+ glutamine to creatine were calculated. In midparietal gray matter spectra, we found a significant decrease in the absolute concentration of NAA in OT patients versus healthy controls (7.76± 0.25 vs 8.11± 0.45, P= 0.017). A similar decrease in NAA was seen in the cerebellar vermis (7.33± 0.61 vs 8.55± 1.54, P= 0.014) and cerebellar white matter (8.54± 0.79 vs 9.95± 1.57, P= 0.010). No differences in the other metabolites or their ratios were observed. Reductions in both cerebral cortical and cerebellar NAA suggest that there is neuronal damage or loss in OT, raising the intriguing question as to whether OT is a neurodegenerative disease. Along with clinical history and electrophysio0logical examination, 1H-MRS could serve as a useful diagnostic aid for OT.

Original languageEnglish (US)
Article numbere4848
JournalMedicine (United States)
Volume95
Issue number37
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Case-control study
  • Cerebellum
  • Magnetic resonance imaging
  • Orthostatic tremor
  • Pathophysiology
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Benito-León, J., Louis, E. D., Mato-Abad, V., Dydak, U., Álvarez-Linera, J., Hernández-Tamames, J. A., Molina-Arjona, J. A., Malpica, N., Matarazzo, M., Romero, J. P., & Sánchez-Ferro, Á. (2016). In vivo neurometabolic profiling in orthostatic tremor. Medicine (United States), 95(37), [e4848]. https://doi.org/10.1097/MD.0000000000004848