In vivo off-resonance saturation magnetic resonance imaging of α vβ 3-targeted superparamagnetic nanoparticles

Chalermchai Khemtong, Chase W. Kessinger, Jimin Ren, Erik A. Bey, Su Geun Yang, Jagadeesh Setti Guthi, David A. Boothman, A. Dean Sherry, Jinming Gao

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Magnetic resonance imaging is a powerful clinical imaging technique that allows for noninvasive tomographic visualization of anatomic structures with high spatial resolution and soft tissue contrast. However, its application in molecular imaging of cancer has been limited by the lack of sensitivity and detection accuracy in depicting the biochemical expression of these diseases. Here, we combine an ultrasensitive design of superparamagnetic polymeric micelles (SPPM) and an off-resonance saturation (ORS) method to enhance the imaging efficacy of tumor biomarkers in vivo. SPPM nano-particles encoded with cyclic(RGDfK) were able to target the α vβ 3- expressing microvasculature in A549 non-small cell lung tumor xenografts in mice. ORS greatly improved tumor detection accuracy over the conventional T 2 *-weighted method by its ability to turn "ON" the contrast of SPPM. This combination of ORS imaging with a tumor vasculature-targeted, ultrasensitive SPPM design offers new opportunities in molecular imaging of cancer.

Original languageEnglish (US)
Pages (from-to)1651-1658
Number of pages8
JournalCancer research
Volume69
Issue number4
DOIs
StatePublished - Feb 15 2009

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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