In Vivo Reprogramming for Brain and Spinal Cord Repair

Gong Chen, Marius Wernig, Benedikt Berninger, Masato Nakafuku, Malin Parmar, Chun Li Zhang

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC.

Original languageEnglish (US)
JournaleNeuro
Volume2
Issue number5
DOIs
StatePublished - Sep 1 2015

Keywords

  • astrocyte
  • brain repair
  • in vivo
  • neuron
  • NG2 cell
  • reprogramming

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Chen, G., Wernig, M., Berninger, B., Nakafuku, M., Parmar, M., & Zhang, C. L. (2015). In Vivo Reprogramming for Brain and Spinal Cord Repair. eNeuro, 2(5). https://doi.org/10.1523/ENEURO.0106-15.2015