In vivo stereological assessment of caudate volume in man: Effect of normal aging

K. Ranga Krishnan, M. M. Husain, W. M. McDonald, P. M. Doraiswamy, G. S. Figiel, O. B. Boyko, E. H. Ellinwood, C. B. Nemeroff

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

Original languageEnglish (US)
Pages (from-to)1325-1329
Number of pages5
JournalLife Sciences
Volume47
Issue number15
DOIs
StatePublished - 1990

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Caudate Nucleus
Brain
Aging of materials
Magnetic resonance
Sampling
Imaging techniques
Autopsy
Healthy Volunteers
Magnetic Resonance Imaging
Research

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ranga Krishnan, K., Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Boyko, O. B., ... Nemeroff, C. B. (1990). In vivo stereological assessment of caudate volume in man: Effect of normal aging. Life Sciences, 47(15), 1325-1329. https://doi.org/10.1016/0024-3205(90)90196-X

In vivo stereological assessment of caudate volume in man : Effect of normal aging. / Ranga Krishnan, K.; Husain, M. M.; McDonald, W. M.; Doraiswamy, P. M.; Figiel, G. S.; Boyko, O. B.; Ellinwood, E. H.; Nemeroff, C. B.

In: Life Sciences, Vol. 47, No. 15, 1990, p. 1325-1329.

Research output: Contribution to journalArticle

Ranga Krishnan, K, Husain, MM, McDonald, WM, Doraiswamy, PM, Figiel, GS, Boyko, OB, Ellinwood, EH & Nemeroff, CB 1990, 'In vivo stereological assessment of caudate volume in man: Effect of normal aging', Life Sciences, vol. 47, no. 15, pp. 1325-1329. https://doi.org/10.1016/0024-3205(90)90196-X
Ranga Krishnan K, Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Boyko OB et al. In vivo stereological assessment of caudate volume in man: Effect of normal aging. Life Sciences. 1990;47(15):1325-1329. https://doi.org/10.1016/0024-3205(90)90196-X
Ranga Krishnan, K. ; Husain, M. M. ; McDonald, W. M. ; Doraiswamy, P. M. ; Figiel, G. S. ; Boyko, O. B. ; Ellinwood, E. H. ; Nemeroff, C. B. / In vivo stereological assessment of caudate volume in man : Effect of normal aging. In: Life Sciences. 1990 ; Vol. 47, No. 15. pp. 1325-1329.
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