In vivo thrombus formation on a guidewire during intravascular ultrasound imaging: Evidence for inadequate heparinization

P. A. Grayburn, J. E. Willard, M. E. Brickner, E. J. Eichhorn

Research output: Contribution to journalArticle

32 Scopus citations


We present a case in which thrombus formation on a guidewire was visualized during intravascular ultrasound imaging despite the administration of 10,000 units of heparin sulfate prior to the procedure. Gross thrombus formation was confirmed upon removal of the guidewire. The activated clotting time was found to be 191 s, suggesting heparin resistance. This report graphically illustrates the potential thrombogenicity associated with intravascular guidewire manipulation during procedures such as intravascular ultrasound imaging and percutaneous transluminal coronary angioplasty. Moreover, this case suggests that adequate heparinization should be routinely verified by measuring the activated clotting time prior to introducing a guidewire into the arterial system.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalCatheterization and Cardiovascular Diagnosis
Issue number2
StatePublished - Jun 1991



  • anticoagulation
  • coronary artery disease
  • echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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