In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice

Linda M. Kalikin, Abraham Schneider, Melissa A. Thakur, Yaron Fridman, Laura B. Griffin, Rodney L. Dunn, Thomas J. Rosol, Rajal B. Shah, Alnawaz Rehemtulla, Laurie K. McCauley, Kenneth J. Pienta

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

While survival periods for patients with localized prostate cancer have increased, there is still no curative therapy for metastatic disease. Using non-invasive bioluminescent imaging, we designed a comprehensive murine model to monitor tumor location and expansion. We detected micrometastases after one week that correlated by gross necropsy, autoradiography, and histopathology with organ and skeletal lesions seen clinically. We calculated in vivo kinetics for tumor growth based on biophoton emissions and observed significantly faster growth of bone lesions and of overall tumor burden in young mice compared to old mice. This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalCancer Biology and Therapy
Volume2
Issue number6
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Bioluminescence
  • Growth kinetics
  • Luciferase
  • Metastasis
  • PC-3
  • Prostate cancer
  • Xenograft model

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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