In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys

Jing Xu, Mengxiao Yu, Phoebe Carter, Elizabeth Hernandez, Andrew Dang, Payal Kapur, Jer Tsong Hsieh, Jie Zheng

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

With more and more engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understanding of their transport in the different compartments of kidneys becomes increasingly important. Here, we report noninvasive X-ray imaging of renal clearable gold NPs (AuNPs) in normal and nephropathic kidneys. By quantifying the transport kinetics of the AuNPs in cortex, medulla and pelvis of the normal and injured kidneys, we found that ureteral obstruction not just blocked the NP elimination through the ureter but also slowed down their transport from the medulla to pelvis and enhanced the cellular uptake. Moreover, the transport kinetics of the NPs and renal anatomic details can be precisely correlated with local pathological lesion. These findings not only advance our understandings of the nano-bio interactions in kidneys but also offer a new pathway to noninvasively image kidney dysfunction and local injuries at the anatomical level.

Original languageEnglish (US)
Pages (from-to)13356-13360
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number43
DOIs
StatePublished - Oct 16 2017

Keywords

  • Biophysics
  • kidneys
  • nanoparticles
  • renal clearance
  • X-ray imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys'. Together they form a unique fingerprint.

  • Cite this