Abstract
Thymus lymphocytes activated in vitro by a T cell mitogen (concanavalin A (Con A)) did not form Fc rosettes nor were they cytotoxic against untreated or antiserum-coated target cells. Con A activated spleen cells were cytotoxic against target cells, but they did not display an increased cytotoxic effect against antibody-coated YAC targets, when compared to normal spleen cells. Con A-activated spleen cells as well as cells activated by a mixed lymphocyte culture did not form Fc rosettes. Thus, activated cytotoxic T cells did not form Fc rosettes nor did they cause cytotoxicity on antibody-coated target cells. Antibody coating of the target cells did not suppress expression of cytotoxicity of activated T cells.
Original language | English (US) |
---|---|
Pages (from-to) | 374-379 |
Number of pages | 6 |
Journal | Transplantation |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1976 |
ASJC Scopus subject areas
- Transplantation