Inability of normal and activated thymus-derived cells to act as cytotoxic effector cells against antibody-coated targets

James Forman, Sven Britton, Göran Möller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thymus lymphocytes activated in vitro by a T cell mitogen (concanavalin A (Con A)) did not form Fc rosettes nor were they cytotoxic against untreated or antiserum-coated target cells. Con A activated spleen cells were cytotoxic against target cells, but they did not display an increased cytotoxic effect against antibody-coated YAC targets, when compared to normal spleen cells. Con A-activated spleen cells as well as cells activated by a mixed lymphocyte culture did not form Fc rosettes. Thus, activated cytotoxic T cells did not form Fc rosettes nor did they cause cytotoxicity on antibody-coated target cells. Antibody coating of the target cells did not suppress expression of cytotoxicity of activated T cells.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalTransplantation
Volume22
Issue number4
StatePublished - Jan 1 1976

Fingerprint

Thymus Gland
Antibodies
Concanavalin A
Spleen
T-Lymphocytes
Lymphocytes
Mitogens
Immune Sera

ASJC Scopus subject areas

  • Transplantation

Cite this

Inability of normal and activated thymus-derived cells to act as cytotoxic effector cells against antibody-coated targets. / Forman, James; Britton, Sven; Möller, Göran.

In: Transplantation, Vol. 22, No. 4, 01.01.1976, p. 374-379.

Research output: Contribution to journalArticle

@article{2324a8dbdd8a42b285458e04cd67e802,
title = "Inability of normal and activated thymus-derived cells to act as cytotoxic effector cells against antibody-coated targets",
abstract = "Thymus lymphocytes activated in vitro by a T cell mitogen (concanavalin A (Con A)) did not form Fc rosettes nor were they cytotoxic against untreated or antiserum-coated target cells. Con A activated spleen cells were cytotoxic against target cells, but they did not display an increased cytotoxic effect against antibody-coated YAC targets, when compared to normal spleen cells. Con A-activated spleen cells as well as cells activated by a mixed lymphocyte culture did not form Fc rosettes. Thus, activated cytotoxic T cells did not form Fc rosettes nor did they cause cytotoxicity on antibody-coated target cells. Antibody coating of the target cells did not suppress expression of cytotoxicity of activated T cells.",
author = "James Forman and Sven Britton and G{\"o}ran M{\"o}ller",
year = "1976",
month = "1",
day = "1",
language = "English (US)",
volume = "22",
pages = "374--379",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Inability of normal and activated thymus-derived cells to act as cytotoxic effector cells against antibody-coated targets

AU - Forman, James

AU - Britton, Sven

AU - Möller, Göran

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Thymus lymphocytes activated in vitro by a T cell mitogen (concanavalin A (Con A)) did not form Fc rosettes nor were they cytotoxic against untreated or antiserum-coated target cells. Con A activated spleen cells were cytotoxic against target cells, but they did not display an increased cytotoxic effect against antibody-coated YAC targets, when compared to normal spleen cells. Con A-activated spleen cells as well as cells activated by a mixed lymphocyte culture did not form Fc rosettes. Thus, activated cytotoxic T cells did not form Fc rosettes nor did they cause cytotoxicity on antibody-coated target cells. Antibody coating of the target cells did not suppress expression of cytotoxicity of activated T cells.

AB - Thymus lymphocytes activated in vitro by a T cell mitogen (concanavalin A (Con A)) did not form Fc rosettes nor were they cytotoxic against untreated or antiserum-coated target cells. Con A activated spleen cells were cytotoxic against target cells, but they did not display an increased cytotoxic effect against antibody-coated YAC targets, when compared to normal spleen cells. Con A-activated spleen cells as well as cells activated by a mixed lymphocyte culture did not form Fc rosettes. Thus, activated cytotoxic T cells did not form Fc rosettes nor did they cause cytotoxicity on antibody-coated target cells. Antibody coating of the target cells did not suppress expression of cytotoxicity of activated T cells.

UR - http://www.scopus.com/inward/record.url?scp=0017011378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017011378&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 374

EP - 379

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 4

ER -