TY - JOUR
T1 - Inactivation of the Rps4 gene on the mouse X chromosome
AU - Zinn, Andrew R.
AU - Bressler, Steven L.
AU - Beer-Romero, Peggy
AU - Adler, David A.
AU - Chapman, Verne M.
AU - Page, David C.
AU - Disteche, Christine M.
N1 - Funding Information:
We thank Debbie Swiatek for maintaining the T16H breeding colony, and Kris Carroll for preparing figures. We thank Jonathan Bogan, Simon Foote, Eric Lander, Rebecca Mosher, Elizabeth Simpson, and Douglas Vollrath for comments on the manuscript. This work was supported by the National Institutes of Health, the March of Dimes, and the Searle Scholars Program/Chicago Community Trust. A.Z. is supported by a Damon Runyon-Walter Win-chell Cancer Research Fund Fellowship, DRG-052. ’
PY - 1991/12
Y1 - 1991/12
N2 - The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.
AB - The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.
UR - http://www.scopus.com/inward/record.url?scp=0026342521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026342521&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(91)90037-F
DO - 10.1016/0888-7543(91)90037-F
M3 - Article
C2 - 1783379
AN - SCOPUS:0026342521
SN - 0888-7543
VL - 11
SP - 1097
EP - 1101
JO - Genomics
JF - Genomics
IS - 4
ER -