Inactivation of the Rps4 gene on the mouse X chromosome

Andrew R. Zinn, Steven L. Bressler, Peggy Beer-Romero, David A. Adler, Verne M. Chapman, David C. Page, Christine M. Disteche

Research output: Contribution to journalArticle

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Abstract

The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.

Original languageEnglish (US)
Pages (from-to)1097-1101
Number of pages5
JournalGenomics
Volume11
Issue number4
DOIs
StatePublished - 1991

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X Chromosome
Gene Silencing
X Chromosome Inactivation
Turner Syndrome
Genes
Chromosomes, Human, X
Haploinsufficiency
Y Chromosome
Protein Isoforms
Phenotype

ASJC Scopus subject areas

  • Genetics

Cite this

Zinn, A. R., Bressler, S. L., Beer-Romero, P., Adler, D. A., Chapman, V. M., Page, D. C., & Disteche, C. M. (1991). Inactivation of the Rps4 gene on the mouse X chromosome. Genomics, 11(4), 1097-1101. https://doi.org/10.1016/0888-7543(91)90037-F

Inactivation of the Rps4 gene on the mouse X chromosome. / Zinn, Andrew R.; Bressler, Steven L.; Beer-Romero, Peggy; Adler, David A.; Chapman, Verne M.; Page, David C.; Disteche, Christine M.

In: Genomics, Vol. 11, No. 4, 1991, p. 1097-1101.

Research output: Contribution to journalArticle

Zinn, AR, Bressler, SL, Beer-Romero, P, Adler, DA, Chapman, VM, Page, DC & Disteche, CM 1991, 'Inactivation of the Rps4 gene on the mouse X chromosome', Genomics, vol. 11, no. 4, pp. 1097-1101. https://doi.org/10.1016/0888-7543(91)90037-F
Zinn AR, Bressler SL, Beer-Romero P, Adler DA, Chapman VM, Page DC et al. Inactivation of the Rps4 gene on the mouse X chromosome. Genomics. 1991;11(4):1097-1101. https://doi.org/10.1016/0888-7543(91)90037-F
Zinn, Andrew R. ; Bressler, Steven L. ; Beer-Romero, Peggy ; Adler, David A. ; Chapman, Verne M. ; Page, David C. ; Disteche, Christine M. / Inactivation of the Rps4 gene on the mouse X chromosome. In: Genomics. 1991 ; Vol. 11, No. 4. pp. 1097-1101.
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