Inactivation of the Rps4 gene on the mouse X chromosome

Andrew R. Zinn, Steven L. Bressler, Peggy Beer-Romero, David A. Adler, Verne M. Chapman, David C. Page, Christine M. Disteche

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39 Scopus citations

Abstract

The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.

Original languageEnglish (US)
Pages (from-to)1097-1101
Number of pages5
JournalGenomics
Volume11
Issue number4
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Genetics

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    Zinn, A. R., Bressler, S. L., Beer-Romero, P., Adler, D. A., Chapman, V. M., Page, D. C., & Disteche, C. M. (1991). Inactivation of the Rps4 gene on the mouse X chromosome. Genomics, 11(4), 1097-1101. https://doi.org/10.1016/0888-7543(91)90037-F