Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies: A prospective cohort study

Katherine Watts, Jianbo Li, Cristina Magi-Galluzzi, Ming Zhou

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Aims: Intraductal carcinoma of the prostate (IDC-P) is a distinct clinicopathological entity and is associated with aggressive, high-grade and high-volume prostate carcinoma (PCa). The incidence, clinicopathological characteristics and prognostic significance of IDC-P have not been reported in prostate biopsies (PBx) that surgical pathologists encounter in their daily practice. Methods and results: In 1176 prospectively collected PBx, 33 IDC-P cases were identified (2.8%). The mean age of patients with IDC-P was 65 (range 46-79) years and mean serum prostate-specific antigen was 16.2 (range 0.4-105.6) ng/ml. Three (0.26%) IDC-P cases did not have a concomitant invasive PCa. Of 30 cases with concomitant invasive PCa, Gleason score was 7 in 16 (53.3%), 8 in four (13.3%) and 9 in 10 (33.3%) cases. The mean number of biopsy cores involved by PCa was 7.2 (range 1-14). Nine patients were treated with radical prostatectomy. Seminal vesicle invasion was found in four of nine (44%) cases, significantly higher than the risk of 12% predicted by Partin Tables (P = 0.016). Conclusions: This is the first prospective study that has investigated the incidence and prognostic significance of IDC-P diagnosed in PBx encountered in daily practice. It is critical for surgical pathologists to diagnose and report IDC-P in PBx.

Original languageEnglish (US)
Pages (from-to)574-579
Number of pages6
JournalHistopathology
Volume63
Issue number4
DOIs
StatePublished - Oct 1 2013

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Carcinoma, Intraductal, Noninfiltrating
Prostate
Cohort Studies
Prospective Studies
Biopsy
Incidence
Carcinoma
Nomograms
Neoplasm Grading
Seminal Vesicles
Prostate-Specific Antigen
Prostatectomy

Keywords

  • Biopsy
  • Intraductal carcinoma
  • Prognosis
  • Prostate cancer

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies : A prospective cohort study. / Watts, Katherine; Li, Jianbo; Magi-Galluzzi, Cristina; Zhou, Ming.

In: Histopathology, Vol. 63, No. 4, 01.10.2013, p. 574-579.

Research output: Contribution to journalArticle

Watts, Katherine ; Li, Jianbo ; Magi-Galluzzi, Cristina ; Zhou, Ming. / Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies : A prospective cohort study. In: Histopathology. 2013 ; Vol. 63, No. 4. pp. 574-579.
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