Incidence and risk factors for deep venous thrombosis and pulmonary embolus after liver transplantation

Valerie Emuakhagbon, Prejesh Philips, Vatche Agopian, Fady M. Kaldas, Christopher M. Jones

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background Omitting chemical venous thromboembolism prophylaxis in liver transplant recipients may lead to an increase incidence of deep venous thrombosis (DVT) and/or pulmonary embolus (PE). Methods A retrospective comparison of liver transplant recipients who developed postoperative DVT/PE to an age-matched population. Results Forty-three of eight hundred sixty-seven patients developed a DVT/PE. Study group patients received higher amounts of cryoprecipitate and fresh frozen plasma. Study group international normalized ratio (INR) was significantly higher, as was the incidence of postoperative complications. High-grade complication rates (bleeding, respiratory failure, and renal insufficiency) were increased in the study group at 16% vs 0%. Conclusions The present study demonstrates that the rate of DVT/PE after liver transplantation is similar to the rate after other major operations. Patients were more likely to develop DVT/PE if they received increased amounts of intraoperative cryoprecipitate/fresh frozen plasma (FFP) or had an elevated postoperative INR. Furthermore, patients with a complicated postoperative course have the highest risk of venous thromboembolism.

Original languageEnglish (US)
Pages (from-to)768-771
Number of pages4
JournalAmerican Journal of Surgery
Volume211
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Embolism
Venous Thrombosis
Liver Transplantation
Lung
Incidence
International Normalized Ratio
Venous Thromboembolism
Respiratory Insufficiency
Liver
Renal Insufficiency
Hemorrhage
Population
Transplant Recipients

Keywords

  • Anticoagulation
  • DVT
  • Liver transplantation
  • PE

ASJC Scopus subject areas

  • Surgery

Cite this

Incidence and risk factors for deep venous thrombosis and pulmonary embolus after liver transplantation. / Emuakhagbon, Valerie; Philips, Prejesh; Agopian, Vatche; Kaldas, Fady M.; Jones, Christopher M.

In: American Journal of Surgery, Vol. 211, No. 4, 01.04.2016, p. 768-771.

Research output: Contribution to journalArticle

Emuakhagbon, Valerie ; Philips, Prejesh ; Agopian, Vatche ; Kaldas, Fady M. ; Jones, Christopher M. / Incidence and risk factors for deep venous thrombosis and pulmonary embolus after liver transplantation. In: American Journal of Surgery. 2016 ; Vol. 211, No. 4. pp. 768-771.
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