Incidence of and risk factors for skin cancer in organ transplant recipients in the United States

Giorgia L. Garrett, Paul D. Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L. Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y. Cheng, Zelma Chiesa-Fuxench, Oscar R. Colegio, Clara Curiel-Lewandrowski, Christina A. Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline MorrisSpring K. Golden, Michael S. Graves, John R. Griffin, R. Samuel Hopkins, Conway C. Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A. Jennings, Shang I.Brian Jiang, Pritesh S. Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A. Koyfman, Charlene Lam, Peter Lee, Justin J. Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F. Moreau, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H. Patel, Vishal Anil Patel, Arpan V. Prabhu, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah Schram, Allen F. Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A. Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T. Arron

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Abstract

IMPORTANCE Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States. OBJECTIVE To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ transplant in 2003 or 2008. DESIGN, SETTING, AND PARTICIPANTS This multicenter retrospective cohort study examined 10 649 adult recipients of a primary transplant performed at 26 centers across the United States in the Transplant Skin Cancer Network during 1 of 2 calendar years (either 2003 or 2008) identified through the Organ Procurement and Transplantation Network (OPTN) database. Recipients of all organs except intestine were included, and the follow-up periods were 5 and 10 years. MAIN OUTCOMES AND MEASURES Incident skin cancerwas determined through detailed medical record review. Data on predictors were obtained from the OPTN database. The incidence rates for posttransplant skin cancer overall and for SCC, MM, and MCC were calculated per 100 000 person-years. Potential risk factors for posttransplant skin cancer were tested using multivariate Cox regression analysis to yield adjusted hazard ratios (HR). RESULTS Overall, 10 649 organ transplant recipients (mean [SD] age, 51 [12] years; 3873 women [36%] and 6776 men [64%]) contributed 59 923 years of follow-up. The incidence rates for posttransplant skin cancer was 1437 per 100 000 person-years. Specific subtype rates for SCC, MM, and MCC were 812, 75, and 2 per 100 000 person-years, respectively. Statistically significant risk factors for posttransplant skin cancer included pretransplant skin cancer (HR, 4.69; 95%CI, 3.26-6.73), male sex (HR, 1.56; 95%CI, 1.34-1.81), white race (HR, 9.04; 95%CI, 6.20-13.18), age at transplant 50 years or older (HR, 2.77; 95%CI, 2.20-3.48), and being transplanted in 2008 vs 2003 (HR, 1.53; 95%CI, 1.22-1.94). CONCLUSIONS AND RELEVANCE Posttransplant skin cancer is common, with elevated risk imparted by increased age, white race, male sex, and thoracic organ transplantation. A temporal cohort effect was present. Understanding the risk factors and trends in posttransplant skin cancer is fundamental to targeted screening and prevention in this population.

Original languageEnglish (US)
Pages (from-to)296-303
Number of pages8
JournalJAMA Dermatology
Volume153
Issue number3
DOIs
StatePublished - Mar 1 2017

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ASJC Scopus subject areas

  • Dermatology

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Garrett, G. L., Blanc, P. D., Boscardin, J., Lloyd, A. A., Ahmed, R. L., Anthony, T., Bibee, K., Breithaupt, A., Cannon, J., Chen, A., Cheng, J. Y., Chiesa-Fuxench, Z., Colegio, O. R., Curiel-Lewandrowski, C., Del Guzzo, C. A., Disse, M., Dowd, M., Eilers, R., Ortiz, A. E., ... Arron, S. T. (2017). Incidence of and risk factors for skin cancer in organ transplant recipients in the United States. JAMA Dermatology, 153(3), 296-303. https://doi.org/10.1001/jamadermatol.2016.4920