TY - JOUR
T1 - Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with heart failure treated with combined cardiac resynchronization plus implantable cardioverter-defibrillator therapy versus implantable cardioverter-defibrillator therapy
AU - Desai, Harit
AU - Aronow, Wilbert S.
AU - Ahn, Chul
AU - Tsai, Fausan S.
AU - Lai, Hoang M.
AU - Gandhi, Kaushang
AU - Amin, Harshad
AU - Frishman, William H.
AU - Kalapatapu, Kumar
AU - Cohen, Martin
AU - Sorbera, Carmine
PY - 2010/3
Y1 - 2010/3
N2 - Of 529 patients with heart failure and a mean left ventricular ejection fraction of 29%, 209 (40%) were treated with cardiac resynchronization therapy (CRT) plus an implantable cardioverter-defibrillator (ICD) and 320 (60%) with an ICD. Mean follow-up was 34 months for both groups. Stepwise logistic regression analysis showed that significant independent variables for appropriate ICD shocks were statins (risk ratio = 0.35, P <.0001), smoking (risk ratio = 2.52, P <.0001), and digoxin (risk ratio = 1.92, P =.0001). Significant independent variables for time to deaths were use of CRT (risk ratio = 0.32, P =.0006), statins (risk ratio = 0.18, P <.0001), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (risk ratio = 0.10, P <.0001), hypertension (risk ratio = 24.15, P <.0001), diabetes (risk ratio = 2.54, P =.0005), and age (risk ratio = 1.06, P <.0001). In conclusion, statins reduced and smoking and digoxin increased appropriate ICD shocks. Use of CRT, statins, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers reduced mortality and hypertension, diabetes, and older age increased mortality.
AB - Of 529 patients with heart failure and a mean left ventricular ejection fraction of 29%, 209 (40%) were treated with cardiac resynchronization therapy (CRT) plus an implantable cardioverter-defibrillator (ICD) and 320 (60%) with an ICD. Mean follow-up was 34 months for both groups. Stepwise logistic regression analysis showed that significant independent variables for appropriate ICD shocks were statins (risk ratio = 0.35, P <.0001), smoking (risk ratio = 2.52, P <.0001), and digoxin (risk ratio = 1.92, P =.0001). Significant independent variables for time to deaths were use of CRT (risk ratio = 0.32, P =.0006), statins (risk ratio = 0.18, P <.0001), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (risk ratio = 0.10, P <.0001), hypertension (risk ratio = 24.15, P <.0001), diabetes (risk ratio = 2.54, P =.0005), and age (risk ratio = 1.06, P <.0001). In conclusion, statins reduced and smoking and digoxin increased appropriate ICD shocks. Use of CRT, statins, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers reduced mortality and hypertension, diabetes, and older age increased mortality.
KW - Cardiac resynchronization therapy
KW - Cardioverter-defibrillator shocks
KW - Heart failure
KW - Implantable cardioverter-defibrillator
KW - Mortality
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U2 - 10.1177/1074248409351408
DO - 10.1177/1074248409351408
M3 - Article
C2 - 19966176
AN - SCOPUS:76649112719
SN - 1074-2484
VL - 15
SP - 37
EP - 40
JO - Journal of Cardiovascular Pharmacology and Therapeutics
JF - Journal of Cardiovascular Pharmacology and Therapeutics
IS - 1
ER -