Incidence of hip osteonecrosis among renal transplantation recipients: A prospective study

R. Lopez-Ben, T. R. Mikuls, D. S. Moore, B. A. Julian, W. K. Bernreuter, M. Elkins, Kenneth G. Saag

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Abstract

Aim: To investigate whether a lessened glucocorticoid cumulative dose would lead to a decreased incidence of femoral head osteonecrosis. Methods: Newly transplanted in-patients (n = 49) underwent hip radiographs and magnetic resonance imaging (MRI) a mean of 17.0 ± 4.3 (range 8-29) days after renal transplantation. For the 48 patients without evidence of prevalent osteonecrosis, imaging at a mean of 5.9 ± 0.8 (range 4.8-8.7) months after renal transplantation was graded for presence/absence of femoral head osteonecrosis by two blinded radiologists. Sociodemographic and disease characteristics of patients were compared to identify potential associations with incident osteonecrosis. Results: At 6-month follow-up, only two patients (4%) had osteonecrosis of the femoral head (three hips). The two primary radiologists had excellent agreement between osteonecrosis diagnosis (kappa coefficient = 0.78). Both cases of a definite MRI diagnosis of osteonecrosis occurred in patients who were in the highest tertile of glucocorticoid dosage. Conclusion: Osteonecrosis was uncommon among a prospective cohort of renal transplant recipients within 6 months after engraftment.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalClinical Radiology
Volume59
Issue number5
DOIs
StatePublished - May 2004

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Keywords

  • Bones
  • Glucocorticoids
  • Kidney transplantation
  • Magnetic resonance (MR)
  • Necrosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Lopez-Ben, R., Mikuls, T. R., Moore, D. S., Julian, B. A., Bernreuter, W. K., Elkins, M., & Saag, K. G. (2004). Incidence of hip osteonecrosis among renal transplantation recipients: A prospective study. Clinical Radiology, 59(5), 431-438. https://doi.org/10.1016/j.crad.2003.11.001