Incidence of intraductal carcinoma, multifocality and bilateral significant disease in radical prostatectomy specimens from Japan and United States

Yu Ching Peng, Toyonori Tsuzuki, Max Xiangtian Kong, Jianhong Li, Fang Ming Deng, Jonathan Melamed, Ming Zhou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Significant differences, including epidemiologic, clinical, pathologic and genetic, exist between Asian and Caucasian prostate cancer. Detailed pathologic data are, however, scarce. We studied in detail and compared the pathological features of prostate cancer in radical prostatectomy specimens in 228 patients (117 Japan, 111 US). Japanese prostate cancer had a higher Gleason grade group (mean 2.67 vs. 2.42 US, P < 0.05), but lower pathological stage (72 % pT2 and 28 % pT3 vs 55 % pT2 and 45 % pT3 US, P < 0.05). Japanese cancer showed significantly more tumor foci (3.8 vs 2.9 US, P < 0.05), and higher incidence of bilateral significant disease (81.3 % vs. 66.7 % US, P < 0.05). The dominant tumor nodules in Japanese cases had higher Gleason grade group (mean 2.73 vs. 2.40 US, P < 0.05). The incidence of intraductal carcinoma was significantly higher in Japanese patients (35.3 % vs. 12.6 % US, P < 0.01), which was independent of Gleason score (7: 30.9 % Japan vs 11.8 % US, P < 0.01; ≥ 8: 87.5 % Japan vs 28.6 % US, P < 0.01) and tumor stage (pT2: 24.1 % Japan vs 6.6 % US, P < 0.01; pT3: 62.9 % Japan vs 20 % US, P < 0.01). These findings demonstrate distinct pathological features in prostate cancer between Japanese and Caucasian patients, and may have important diagnostic and therapeutic implications.

Original languageEnglish (US)
Pages (from-to)672-677
Number of pages6
JournalPathology International
Volume66
Issue number12
DOIs
StatePublished - Dec 1 2016

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Carcinoma, Intraductal, Noninfiltrating
Prostatectomy
Japan
Prostatic Neoplasms
Incidence
Neoplasms
Neoplasm Grading

Keywords

  • ethnicity
  • intraductal carcinoma
  • pathology
  • prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Incidence of intraductal carcinoma, multifocality and bilateral significant disease in radical prostatectomy specimens from Japan and United States. / Peng, Yu Ching; Tsuzuki, Toyonori; Kong, Max Xiangtian; Li, Jianhong; Deng, Fang Ming; Melamed, Jonathan; Zhou, Ming.

In: Pathology International, Vol. 66, No. 12, 01.12.2016, p. 672-677.

Research output: Contribution to journalArticle

Peng, Yu Ching ; Tsuzuki, Toyonori ; Kong, Max Xiangtian ; Li, Jianhong ; Deng, Fang Ming ; Melamed, Jonathan ; Zhou, Ming. / Incidence of intraductal carcinoma, multifocality and bilateral significant disease in radical prostatectomy specimens from Japan and United States. In: Pathology International. 2016 ; Vol. 66, No. 12. pp. 672-677.
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abstract = "Significant differences, including epidemiologic, clinical, pathologic and genetic, exist between Asian and Caucasian prostate cancer. Detailed pathologic data are, however, scarce. We studied in detail and compared the pathological features of prostate cancer in radical prostatectomy specimens in 228 patients (117 Japan, 111 US). Japanese prostate cancer had a higher Gleason grade group (mean 2.67 vs. 2.42 US, P < 0.05), but lower pathological stage (72 {\%} pT2 and 28 {\%} pT3 vs 55 {\%} pT2 and 45 {\%} pT3 US, P < 0.05). Japanese cancer showed significantly more tumor foci (3.8 vs 2.9 US, P < 0.05), and higher incidence of bilateral significant disease (81.3 {\%} vs. 66.7 {\%} US, P < 0.05). The dominant tumor nodules in Japanese cases had higher Gleason grade group (mean 2.73 vs. 2.40 US, P < 0.05). The incidence of intraductal carcinoma was significantly higher in Japanese patients (35.3 {\%} vs. 12.6 {\%} US, P < 0.01), which was independent of Gleason score (7: 30.9 {\%} Japan vs 11.8 {\%} US, P < 0.01; ≥ 8: 87.5 {\%} Japan vs 28.6 {\%} US, P < 0.01) and tumor stage (pT2: 24.1 {\%} Japan vs 6.6 {\%} US, P < 0.01; pT3: 62.9 {\%} Japan vs 20 {\%} US, P < 0.01). These findings demonstrate distinct pathological features in prostate cancer between Japanese and Caucasian patients, and may have important diagnostic and therapeutic implications.",
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