TY - JOUR
T1 - Incidence of musculoskeletal and neoplastic diseases in patients on statin therapy
T2 - Results of a retrospective cohort analysis
AU - Mansi, Ishak A.
AU - Mortensen, Eric M.
AU - Pugh, Mary J.
AU - Wegner, Michael
AU - Frei, Christopher R.
N1 - Funding Information:
C.R. Frei is supported by the U.S. National Institutes of Health (NIH) in the form of an NIH KL2 career development award (RR025766). In addition, he also received research grants and/or served as a scientific consultant/advisor for AstraZeneca, Bristol-Myers Squibb, Elan, Forest, Ortho-McNeil Janssen and Pfizer.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2013/5
Y1 - 2013/5
N2 - BACKGROUND: Because of their beneficial cardiovascular effects, several studies have recently advocated starting statins at a young age for primary prevention. However, some reports suggest that statin therapy may be associated with an increased incidence of musculoskeletal and neoplastic diseases. This study was conducted to investigate the incidence of various musculoskeletal and neoplastic diseases in statin users and nonusers. METHODS: A retrospective cohort study of patients in the San Antonio Military Multi-Service Market during the period from October 1, 2003, to March 5, 2010, was conducted. The International Classification of Diseases, 9th edition, diagnosis codes between 2 cohort groups - statin users and nonusers - were compared. Statin users were those patients with at least one 3-month prescription for a statin in the fiscal year 2004. Nonusers were those patients who received a prescription - but not a statin - during the period of the study. Both groups were assessed for the development of musculoskeletal and neoplastic diseases in the following 4-year period (October 1, 2004, to September 30, 2009). RESULTS: A total of 92,360 patients were identified: 12,980 statin users and 45,997 nonusers. After adjusting for age, sex and Charlson comorbidity index, statin users had significantly higher rates of osteoarthritis and arthropathy (odds ratio: 1.26; 95% confidence interval: 1.19-1.33), and dorsopathies, rheumatism and chondropathies (odds ratio: 1.20; 95% confidence interval: 1.12-1.27). CONCLUSIONS: In this retrospective analysis, statin use was associated with an increased incidence of musculoskeletal diseases, including arthropathy. Further studies are needed to provide physicians and their patients with adequate information regarding statin therapy, particularly if recommended for primary prevention in younger populations.
AB - BACKGROUND: Because of their beneficial cardiovascular effects, several studies have recently advocated starting statins at a young age for primary prevention. However, some reports suggest that statin therapy may be associated with an increased incidence of musculoskeletal and neoplastic diseases. This study was conducted to investigate the incidence of various musculoskeletal and neoplastic diseases in statin users and nonusers. METHODS: A retrospective cohort study of patients in the San Antonio Military Multi-Service Market during the period from October 1, 2003, to March 5, 2010, was conducted. The International Classification of Diseases, 9th edition, diagnosis codes between 2 cohort groups - statin users and nonusers - were compared. Statin users were those patients with at least one 3-month prescription for a statin in the fiscal year 2004. Nonusers were those patients who received a prescription - but not a statin - during the period of the study. Both groups were assessed for the development of musculoskeletal and neoplastic diseases in the following 4-year period (October 1, 2004, to September 30, 2009). RESULTS: A total of 92,360 patients were identified: 12,980 statin users and 45,997 nonusers. After adjusting for age, sex and Charlson comorbidity index, statin users had significantly higher rates of osteoarthritis and arthropathy (odds ratio: 1.26; 95% confidence interval: 1.19-1.33), and dorsopathies, rheumatism and chondropathies (odds ratio: 1.20; 95% confidence interval: 1.12-1.27). CONCLUSIONS: In this retrospective analysis, statin use was associated with an increased incidence of musculoskeletal diseases, including arthropathy. Further studies are needed to provide physicians and their patients with adequate information regarding statin therapy, particularly if recommended for primary prevention in younger populations.
KW - Arthropathy
KW - Musculoskeletal
KW - Neoplasm
KW - Side effects
KW - Statin
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U2 - 10.1097/MAJ.0b013e31825b8edf
DO - 10.1097/MAJ.0b013e31825b8edf
M3 - Article
C2 - 22975580
AN - SCOPUS:84876871524
SN - 0002-9629
VL - 345
SP - 343
EP - 348
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 5
ER -