Incidence of Mycobacterium avium-intracellulare complex bacteremia in human immunodeficiency virus-positive patients

Stephen D. Nightingale, Linda T. Byrd, Paul M. Southern, Jonathan D. Jockusch, Stanley X. Cal, Beverley A. Wynne

Research output: Contribution to journalArticle

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Abstract

The product-limit incidence of Mycobacterium avium-intracellulare complex (MAC) bacteremia in 1006 human immunodeficiency virus (HIV)-positive patients followed at one institution over a 3-year period from the day of AIDS diagnosis with monthly lysis-centrifugation blood cultures was 21% ± 2% SE at 1 year and 43% ± 3% at 2 years. The product-limit incidence of MAC bacteremia at 1 year after the patients' first CD4 cell count was related to both the CD4 cell count and to whether they had an AIDS diagnosis (both P < .0001) but not to age, sex, or race. This incidence was 39% ± 6% for CD4 cell counts of <10/mm3, 30% ± 5% for 10-19/mm3, 20% ± 4% for 20-39/mm3, 15% ± 4% for 40-59/mm3, 8% ± 3% for 60-99/mm3, and 3% ± 1% for 100-199/mm3. MAC may eventually infect most if not all HIV-positive patients who do not die from another HIV-related event.

Original languageEnglish (US)
Pages (from-to)1082-1085
Number of pages4
JournalJournal of Infectious Diseases
Volume165
Issue number6
StatePublished - Jun 1992

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Mycobacterium avium Complex
CD4 Lymphocyte Count
Bacteremia
HIV
Incidence
Acquired Immunodeficiency Syndrome
Centrifugation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Incidence of Mycobacterium avium-intracellulare complex bacteremia in human immunodeficiency virus-positive patients. / Nightingale, Stephen D.; Byrd, Linda T.; Southern, Paul M.; Jockusch, Jonathan D.; Cal, Stanley X.; Wynne, Beverley A.

In: Journal of Infectious Diseases, Vol. 165, No. 6, 06.1992, p. 1082-1085.

Research output: Contribution to journalArticle

Nightingale, Stephen D. ; Byrd, Linda T. ; Southern, Paul M. ; Jockusch, Jonathan D. ; Cal, Stanley X. ; Wynne, Beverley A. / Incidence of Mycobacterium avium-intracellulare complex bacteremia in human immunodeficiency virus-positive patients. In: Journal of Infectious Diseases. 1992 ; Vol. 165, No. 6. pp. 1082-1085.
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