Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic

Amit Chhabra, Wilbert S. Aronow, Chul Ahn, Kurt Duncan, Jay D. Patel, Alexander I. Papolos, Babu Sateesh

Research output: Contribution to journalArticle

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Abstract

Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63%) with PAD at 33-month follow-up and in 21 of 89 patients (24%) without PAD at 48-month follow-up (p<0.0001). Death occurred in 112 of 414 patients (27%) with PAD and in 10 of 89 patients (11%) without PAD (p=0.002). Stepwise Cox regression analysis for the time to at least one of the 6 outcomes showed that significant independent risk factors were men (hazard ratio =1.394; 95% CI, 1.072-1.813; p=0.013), estimated glomerular filtration rate (hazard ratio =0.992; 95% CI, 0.987-0.997; p=0.003), and PAD (hazard ratio =3.520; 95% CI, 2.196-5.641; p<0.0001). Stepwise Cox regression analysis for the time to death showed that significant independent risk factors were age (hazard ratio =1.024; 95% CI, 1.000-1.049; p=0.048), estimated glomerular filtration rate (hazard ratio =0.985; 95% CI, 0.974-0.996; p=0.007), and PAD (hazard ratio =2.157; 95% CI, 1.118-4.160; p=0.022).Conclusions: Patients with PAD have a significantly higher incidence of cardiovascular outcomes, especially death, new PAD revascularization, and new carotid endarterectomy, than patients without PAD followed in a vascular surgery clinic.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume18
Issue number3
StatePublished - 2012

Fingerprint

Peripheral Arterial Disease
Blood Vessels
Incidence
Carotid Endarterectomy
Glomerular Filtration Rate
Regression Analysis
Transient Ischemic Attack
Stroke
Myocardial Infarction

Keywords

  • Carotid endarterectomy
  • Coronary revascularization
  • Glomerular filtration rate
  • Myocardial infarction
  • Noncoronary revascularization
  • Peripheral arterial disease
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic. / Chhabra, Amit; Aronow, Wilbert S.; Ahn, Chul; Duncan, Kurt; Patel, Jay D.; Papolos, Alexander I.; Sateesh, Babu.

In: Medical Science Monitor, Vol. 18, No. 3, 2012.

Research output: Contribution to journalArticle

Chhabra, Amit ; Aronow, Wilbert S. ; Ahn, Chul ; Duncan, Kurt ; Patel, Jay D. ; Papolos, Alexander I. ; Sateesh, Babu. / Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic. In: Medical Science Monitor. 2012 ; Vol. 18, No. 3.
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abstract = "Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63{\%}) with PAD at 33-month follow-up and in 21 of 89 patients (24{\%}) without PAD at 48-month follow-up (p<0.0001). Death occurred in 112 of 414 patients (27{\%}) with PAD and in 10 of 89 patients (11{\%}) without PAD (p=0.002). Stepwise Cox regression analysis for the time to at least one of the 6 outcomes showed that significant independent risk factors were men (hazard ratio =1.394; 95{\%} CI, 1.072-1.813; p=0.013), estimated glomerular filtration rate (hazard ratio =0.992; 95{\%} CI, 0.987-0.997; p=0.003), and PAD (hazard ratio =3.520; 95{\%} CI, 2.196-5.641; p<0.0001). Stepwise Cox regression analysis for the time to death showed that significant independent risk factors were age (hazard ratio =1.024; 95{\%} CI, 1.000-1.049; p=0.048), estimated glomerular filtration rate (hazard ratio =0.985; 95{\%} CI, 0.974-0.996; p=0.007), and PAD (hazard ratio =2.157; 95{\%} CI, 1.118-4.160; p=0.022).Conclusions: Patients with PAD have a significantly higher incidence of cardiovascular outcomes, especially death, new PAD revascularization, and new carotid endarterectomy, than patients without PAD followed in a vascular surgery clinic.",
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T1 - Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic

AU - Chhabra, Amit

AU - Aronow, Wilbert S.

AU - Ahn, Chul

AU - Duncan, Kurt

AU - Patel, Jay D.

AU - Papolos, Alexander I.

AU - Sateesh, Babu

PY - 2012

Y1 - 2012

N2 - Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63%) with PAD at 33-month follow-up and in 21 of 89 patients (24%) without PAD at 48-month follow-up (p<0.0001). Death occurred in 112 of 414 patients (27%) with PAD and in 10 of 89 patients (11%) without PAD (p=0.002). Stepwise Cox regression analysis for the time to at least one of the 6 outcomes showed that significant independent risk factors were men (hazard ratio =1.394; 95% CI, 1.072-1.813; p=0.013), estimated glomerular filtration rate (hazard ratio =0.992; 95% CI, 0.987-0.997; p=0.003), and PAD (hazard ratio =3.520; 95% CI, 2.196-5.641; p<0.0001). Stepwise Cox regression analysis for the time to death showed that significant independent risk factors were age (hazard ratio =1.024; 95% CI, 1.000-1.049; p=0.048), estimated glomerular filtration rate (hazard ratio =0.985; 95% CI, 0.974-0.996; p=0.007), and PAD (hazard ratio =2.157; 95% CI, 1.118-4.160; p=0.022).Conclusions: Patients with PAD have a significantly higher incidence of cardiovascular outcomes, especially death, new PAD revascularization, and new carotid endarterectomy, than patients without PAD followed in a vascular surgery clinic.

AB - Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63%) with PAD at 33-month follow-up and in 21 of 89 patients (24%) without PAD at 48-month follow-up (p<0.0001). Death occurred in 112 of 414 patients (27%) with PAD and in 10 of 89 patients (11%) without PAD (p=0.002). Stepwise Cox regression analysis for the time to at least one of the 6 outcomes showed that significant independent risk factors were men (hazard ratio =1.394; 95% CI, 1.072-1.813; p=0.013), estimated glomerular filtration rate (hazard ratio =0.992; 95% CI, 0.987-0.997; p=0.003), and PAD (hazard ratio =3.520; 95% CI, 2.196-5.641; p<0.0001). Stepwise Cox regression analysis for the time to death showed that significant independent risk factors were age (hazard ratio =1.024; 95% CI, 1.000-1.049; p=0.048), estimated glomerular filtration rate (hazard ratio =0.985; 95% CI, 0.974-0.996; p=0.007), and PAD (hazard ratio =2.157; 95% CI, 1.118-4.160; p=0.022).Conclusions: Patients with PAD have a significantly higher incidence of cardiovascular outcomes, especially death, new PAD revascularization, and new carotid endarterectomy, than patients without PAD followed in a vascular surgery clinic.

KW - Carotid endarterectomy

KW - Coronary revascularization

KW - Glomerular filtration rate

KW - Myocardial infarction

KW - Noncoronary revascularization

KW - Peripheral arterial disease

KW - Stroke

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JO - Medical Science Monitor

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