Incidence of new stroke or new myocardial infarction or death at 39-month follow-up in patients with diabetes mellitus, hypertension or both with and without microalbuminuria

Gautham Ravipati, Wilbert S. Aronow, Chul Ahn, Rose M. Alappat, John A. McClung, Melvin B. Weiss

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We investigated in 306 patients, mean age 57 ± 10 years, with diabetes mellitus (202 patients) or hypertension (179 patients) whether microalbuminuria was a significant independent risk factor for the development of new stroke or new myocardial infarction (MI) or death. At 39-month follow-up, new stroke or new MI or death developed in 44 of 111 patients (40%) with microalbuminuria and in 38 of 195 patients (19%) without microalbuminuria (p = 0.0001). Stepwise Cox regression analysis showed that significant independent predictors of the time to development of new stroke or new MI or death were (1) diabetes (risk ratio = 1.76), (2) left ventricular (LV) mass index (risk ratio = 1.020 for each 1 g/m2 increase), (3) prior stroke (risk ratio = 5.39), and (4) prior MI (risk ratio = 3.29). Microalbuminuria was not a significant independent predictor of new stroke or new MI or death, but LV mass index, diabetes mellitus, prior stroke, and prior MI were significant independent predictors.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalCardiology
Volume109
Issue number1
DOIs
StatePublished - Dec 1 2007

Keywords

  • Diabetes mellitus
  • Hypertension
  • Left ventricular hypertrophy
  • Microalbuminuria
  • Myocardial infarction
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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