TY - JOUR
T1 - Incidence of perioperative myocardial infarction and of 2-year mortality in 577 elderly patients undergoing noncardiac vascular surgery treated with and without statins
AU - Desai, Harit
AU - Aronow, Wilbert S.
AU - Ahn, Chul
AU - Gandhi, Kaushang
AU - Amin, Harshad
AU - Lai, Hoang M.
AU - Tsai, Fausan S.
AU - Sharma, Mala
AU - Babu, Sateesh
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Of 577 patients, mean age 74 years, undergoing noncardiac vascular surgery, 300 (52%) had carotid endarterectomy, 179 (31%) had lower extremity revascularization, and 98 (17%) had abdominal aortic aneurysm repair. Of the 577 patients, 302 (52%) were treated with statins. Perioperative myocardial infarction (MI) occurred in 18 of 302 patients (6%) treated with statins and in 38 of 275 patients (14%) not treated with statins (p=0.001). Two-year mortality occurred in 18 of 302 patients (6%) treated with statins and in 43 of 275 patients (16%) not treated with statins (p=0.0002). Perioperative MI or mortality occurred in 34 of 302 patients (11%) treated with statins and in 74 of 275 patients (27%) not treated with statins (p<0.0001). Stepwise Cox regression analysis showed that significant independent prognostic factors for perioperative MI or death were use of statins (risk ratio. =RR. =0.43, p<0.0001), use of beta blockers (RR. =0.55, p=0.002), carotid endarterectomy (RR. =0.60, p=0.009), and diabetes (RR. =1.5, p=0.045). In conclusion, patients undergoing noncardiac vascular surgery treated with statins had a 57% less chance of having perioperative MI or death at 2-year follow-up after controlling for other variables.
AB - Of 577 patients, mean age 74 years, undergoing noncardiac vascular surgery, 300 (52%) had carotid endarterectomy, 179 (31%) had lower extremity revascularization, and 98 (17%) had abdominal aortic aneurysm repair. Of the 577 patients, 302 (52%) were treated with statins. Perioperative myocardial infarction (MI) occurred in 18 of 302 patients (6%) treated with statins and in 38 of 275 patients (14%) not treated with statins (p=0.001). Two-year mortality occurred in 18 of 302 patients (6%) treated with statins and in 43 of 275 patients (16%) not treated with statins (p=0.0002). Perioperative MI or mortality occurred in 34 of 302 patients (11%) treated with statins and in 74 of 275 patients (27%) not treated with statins (p<0.0001). Stepwise Cox regression analysis showed that significant independent prognostic factors for perioperative MI or death were use of statins (risk ratio. =RR. =0.43, p<0.0001), use of beta blockers (RR. =0.55, p=0.002), carotid endarterectomy (RR. =0.60, p=0.009), and diabetes (RR. =1.5, p=0.045). In conclusion, patients undergoing noncardiac vascular surgery treated with statins had a 57% less chance of having perioperative MI or death at 2-year follow-up after controlling for other variables.
KW - Abdominal aortic aneurysm repair
KW - Beta blockers
KW - Carotid endarterectomy
KW - Lower extremity revascularization
KW - Statins
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U2 - 10.1016/j.archger.2009.09.042
DO - 10.1016/j.archger.2009.09.042
M3 - Article
C2 - 19819571
AN - SCOPUS:77955269145
VL - 51
SP - 149
EP - 151
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2
ER -