Incidence of perioperative myocardial infarction and of 2-year mortality in 577 elderly patients undergoing noncardiac vascular surgery treated with and without statins

Harit Desai, Wilbert S. Aronow, Chul Ahn, Kaushang Gandhi, Harshad Amin, Hoang M. Lai, Fausan S. Tsai, Mala Sharma, Sateesh Babu

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Of 577 patients, mean age 74 years, undergoing noncardiac vascular surgery, 300 (52%) had carotid endarterectomy, 179 (31%) had lower extremity revascularization, and 98 (17%) had abdominal aortic aneurysm repair. Of the 577 patients, 302 (52%) were treated with statins. Perioperative myocardial infarction (MI) occurred in 18 of 302 patients (6%) treated with statins and in 38 of 275 patients (14%) not treated with statins (p=0.001). Two-year mortality occurred in 18 of 302 patients (6%) treated with statins and in 43 of 275 patients (16%) not treated with statins (p=0.0002). Perioperative MI or mortality occurred in 34 of 302 patients (11%) treated with statins and in 74 of 275 patients (27%) not treated with statins (p<0.0001). Stepwise Cox regression analysis showed that significant independent prognostic factors for perioperative MI or death were use of statins (risk ratio. =RR. =0.43, p<0.0001), use of beta blockers (RR. =0.55, p=0.002), carotid endarterectomy (RR. =0.60, p=0.009), and diabetes (RR. =1.5, p=0.045). In conclusion, patients undergoing noncardiac vascular surgery treated with statins had a 57% less chance of having perioperative MI or death at 2-year follow-up after controlling for other variables.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalArchives of Gerontology and Geriatrics
Volume51
Issue number2
DOIs
StatePublished - Sep 1 2010

Keywords

  • Abdominal aortic aneurysm repair
  • Beta blockers
  • Carotid endarterectomy
  • Lower extremity revascularization
  • Statins

ASJC Scopus subject areas

  • Health(social science)
  • Aging
  • Gerontology
  • Geriatrics and Gerontology

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