Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic

P. C. Williamson, B. Custer, B. J. Biggerstaff, R. S. Lanciotti, M. H. Sayers, S. J. Eason, M. R. Dixon, V. Winkelman, M. C. Lanteri, L. R. Petersen, M. P. Busch

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The 2012 West Nile virus (WNV) epidemic was the largest since 2003 and the North Texas region was the most heavily impacted. We conducted a serosurvey of blood donors from four counties in the Dallas-Fort Worth area to characterize the epidemic. Blood donor specimens collected in November 2012 were tested for WNV-specific antibodies. Donors positive for WNV-specific IgG, IgM, and neutralizing antibodies were considered to have been infected in 2012. This number was adjusted using a multi-step process that accounted for timing of IgM seroreversion determined from previous longitudinal studies of WNV-infected donors. Of 4971 donations screened, 139 (2·8%) were confirmed WNV IgG positive, and 69 (1·4%) had IgM indicating infection in 2012. After adjusting for timing of sampling and potential seroreversion, we estimated that 1·8% [95% confidence interval (CI) 1·5-2·2] of the adult population in the Dallas-Fort Worth area were infected during 2012. The resulting overall estimate for the ratio of infections to reported WNV neuroinvasive disease (WNND) cases was 238:1 (95% CI 192-290), with significantly increased risk of WNND in older age groups. These findings were very similar to previous estimates of infections per WNND case, indicating no change in virulence as WNV evolved into an endemic infection in the United States.

Original languageEnglish (US)
Pages (from-to)2536-2544
Number of pages9
JournalEpidemiology and Infection
Volume145
Issue number12
DOIs
StatePublished - Sep 1 2017

Fingerprint

West Nile virus
Virus Diseases
Incidence
Immunoglobulin M
Infection
Blood Donors
Immunoglobulin G
Tissue Donors
Confidence Intervals
Neutralizing Antibodies
Longitudinal Studies
Virulence
Age Groups
Antibodies
Population

Keywords

  • Blood transfusion-associated infections
  • incidence
  • West Nile virus

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Williamson, P. C., Custer, B., Biggerstaff, B. J., Lanciotti, R. S., Sayers, M. H., Eason, S. J., ... Busch, M. P. (2017). Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic. Epidemiology and Infection, 145(12), 2536-2544. https://doi.org/10.1017/S0950268816000042

Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic. / Williamson, P. C.; Custer, B.; Biggerstaff, B. J.; Lanciotti, R. S.; Sayers, M. H.; Eason, S. J.; Dixon, M. R.; Winkelman, V.; Lanteri, M. C.; Petersen, L. R.; Busch, M. P.

In: Epidemiology and Infection, Vol. 145, No. 12, 01.09.2017, p. 2536-2544.

Research output: Contribution to journalArticle

Williamson, PC, Custer, B, Biggerstaff, BJ, Lanciotti, RS, Sayers, MH, Eason, SJ, Dixon, MR, Winkelman, V, Lanteri, MC, Petersen, LR & Busch, MP 2017, 'Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic', Epidemiology and Infection, vol. 145, no. 12, pp. 2536-2544. https://doi.org/10.1017/S0950268816000042
Williamson, P. C. ; Custer, B. ; Biggerstaff, B. J. ; Lanciotti, R. S. ; Sayers, M. H. ; Eason, S. J. ; Dixon, M. R. ; Winkelman, V. ; Lanteri, M. C. ; Petersen, L. R. ; Busch, M. P. / Incidence of West Nile virus infection in the Dallas-Fort Worth metropolitan area during the 2012 epidemic. In: Epidemiology and Infection. 2017 ; Vol. 145, No. 12. pp. 2536-2544.
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