TY - JOUR
T1 - IncobotulinumtoxinA in clinical literature.
AU - Lorenc, Z. Paul
AU - Kenkel, Jeffrey M.
AU - Fagien, Steven
AU - Hirmand, Haideh
AU - Nestor, Mark S.
AU - Sclafani, Anthony P.
AU - Sykes, Jonathan M.
AU - Waldorf, Heidi A.
PY - 2013/3
Y1 - 2013/3
N2 - IncobotulinumtoxinA is the third neurotoxin type A to be approved for aesthetic use in the United States. Because incobotulinumtoxinA has been in use in Europe for some time, the clinical literature is fairly replete with references to its properties and characteristics, as well as its safety and efficacy. In North America, 2 pivotal trials, referred to as GL-1 and GL-2, investigated the safety and efficacy of incobotulinumtoxinA in the glabellar region; both are currently in press with another journal. Other published studies of incobotulinumtoxinA are also described in depth in this article, including reports on aesthetic indications, diffusion, therapeutic indications, and studies pertaining to the preclinical and clinical pharmacology of incobotulinumtoxinA. Topics addressed include potency variability, mean concentration, stability and dissociation, and endopeptide immunoassay.
AB - IncobotulinumtoxinA is the third neurotoxin type A to be approved for aesthetic use in the United States. Because incobotulinumtoxinA has been in use in Europe for some time, the clinical literature is fairly replete with references to its properties and characteristics, as well as its safety and efficacy. In North America, 2 pivotal trials, referred to as GL-1 and GL-2, investigated the safety and efficacy of incobotulinumtoxinA in the glabellar region; both are currently in press with another journal. Other published studies of incobotulinumtoxinA are also described in depth in this article, including reports on aesthetic indications, diffusion, therapeutic indications, and studies pertaining to the preclinical and clinical pharmacology of incobotulinumtoxinA. Topics addressed include potency variability, mean concentration, stability and dissociation, and endopeptide immunoassay.
UR - http://www.scopus.com/inward/record.url?scp=84882982343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882982343&partnerID=8YFLogxK
U2 - 10.1177/1090820X12474635
DO - 10.1177/1090820X12474635
M3 - Review article
C2 - 23515196
AN - SCOPUS:84882982343
SN - 1744-165X
VL - 33
SP - 23S-34S
JO - Unknown Journal
JF - Unknown Journal
IS - 1 Suppl
ER -