TY - JOUR
T1 - Increase in transforming growth factor-β in the brain during infection is related to fever, not depression of spontaneous motor activity
AU - Matsumura, S.
AU - Shibakusa, T.
AU - Fujikawa, T.
AU - Yamada, H.
AU - Inoue, K.
AU - Fushiki, T.
PY - 2007/2/9
Y1 - 2007/2/9
N2 - When viral infection occurs, this information is transmitted to the brain, and symptoms such as fever and tiredness are induced. One of the causes of these symptoms is the secretion of proinflammatory cytokines in blood and the brain. In this study, the i.p. administration of polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA, to rats was used as an infection model. Poly I:C decreased spontaneous motor activity (SMA) 2 h after i.p. administration, and this decrease was maintained thereafter. The concentration of active transforming growth factor-β (TGF-β) in cerebrospinal fluid (CSF) increased 1 h after the administration. This increase occurred earlier than those in the concentrations of other proinflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), in serum. The intracisternal administration of an anti-TGF-β antibody partially inhibited fever induced by poly I:C administration; however, this treatment did not affect the decrease in SMA. Furthermore, intracisternal administration of TGF-β raised the body temperature. These results indicate that TGF-β in the brain, which was increased by poly I:C administration, is associated with fever but not with a decrease in SMA.
AB - When viral infection occurs, this information is transmitted to the brain, and symptoms such as fever and tiredness are induced. One of the causes of these symptoms is the secretion of proinflammatory cytokines in blood and the brain. In this study, the i.p. administration of polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA, to rats was used as an infection model. Poly I:C decreased spontaneous motor activity (SMA) 2 h after i.p. administration, and this decrease was maintained thereafter. The concentration of active transforming growth factor-β (TGF-β) in cerebrospinal fluid (CSF) increased 1 h after the administration. This increase occurred earlier than those in the concentrations of other proinflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), in serum. The intracisternal administration of an anti-TGF-β antibody partially inhibited fever induced by poly I:C administration; however, this treatment did not affect the decrease in SMA. Furthermore, intracisternal administration of TGF-β raised the body temperature. These results indicate that TGF-β in the brain, which was increased by poly I:C administration, is associated with fever but not with a decrease in SMA.
KW - cerebrospinal fluid
KW - infection
KW - polyinosinic-polycytidylic acid
KW - proinflammatory cytokine
UR - http://www.scopus.com/inward/record.url?scp=33845883791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845883791&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2006.10.037
DO - 10.1016/j.neuroscience.2006.10.037
M3 - Article
C2 - 17156928
AN - SCOPUS:33845883791
SN - 0306-4522
VL - 144
SP - 1133
EP - 1140
JO - Neuroscience
JF - Neuroscience
IS - 3
ER -