Increased eosinophils in adipose tissue of metabolic syndrome

Karine Moussa, Purnima Gurung, Beverley A Huet, Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

Abstract

Aims: Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. Methods: SAT EOS were quantified by immunohistochemistry. Results: Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. Conclusion: We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StatePublished - Jan 1 2019

Fingerprint

Eosinophils
Adipose Tissue
Leptin
Insulin Resistance
Interleukin-6
Triglycerides
Subcutaneous Fat
Adiponectin
Endotoxins
Type 2 Diabetes Mellitus
Fibrosis
Cardiovascular Diseases
Collagen
Smoking
Immunohistochemistry
Macrophages
Observation
Lymphocytes
Staining and Labeling
Inflammation

Keywords

  • Eosinophils
  • Fibrosis
  • Inflammation
  • Metabolic Syndrome
  • Subcutaneous adipose tissue

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Increased eosinophils in adipose tissue of metabolic syndrome. / Moussa, Karine; Gurung, Purnima; Huet, Beverley A; Devaraj, Sridevi; Jialal, Ishwarlal.

In: Journal of Diabetes and its Complications, 01.01.2019.

Research output: Contribution to journalArticle

Moussa, Karine ; Gurung, Purnima ; Huet, Beverley A ; Devaraj, Sridevi ; Jialal, Ishwarlal. / Increased eosinophils in adipose tissue of metabolic syndrome. In: Journal of Diabetes and its Complications. 2019.
@article{c6e59d95d5714fd9ba14932374eef00a,
title = "Increased eosinophils in adipose tissue of metabolic syndrome",
abstract = "Aims: Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. Methods: SAT EOS were quantified by immunohistochemistry. Results: Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. Conclusion: We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.",
keywords = "Eosinophils, Fibrosis, Inflammation, Metabolic Syndrome, Subcutaneous adipose tissue",
author = "Karine Moussa and Purnima Gurung and Huet, {Beverley A} and Sridevi Devaraj and Ishwarlal Jialal",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jdiacomp.2019.05.010",
language = "English (US)",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Increased eosinophils in adipose tissue of metabolic syndrome

AU - Moussa, Karine

AU - Gurung, Purnima

AU - Huet, Beverley A

AU - Devaraj, Sridevi

AU - Jialal, Ishwarlal

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims: Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. Methods: SAT EOS were quantified by immunohistochemistry. Results: Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. Conclusion: We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.

AB - Aims: Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. Methods: SAT EOS were quantified by immunohistochemistry. Results: Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. Conclusion: We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.

KW - Eosinophils

KW - Fibrosis

KW - Inflammation

KW - Metabolic Syndrome

KW - Subcutaneous adipose tissue

UR - http://www.scopus.com/inward/record.url?scp=85067180687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067180687&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2019.05.010

DO - 10.1016/j.jdiacomp.2019.05.010

M3 - Article

C2 - 31204245

AN - SCOPUS:85067180687

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

ER -