Increased eosinophils in adipose tissue of metabolic syndrome

Karine Moussa, Purnima Gurung, Beverley A Huet, Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Aims: Metabolic Syndrome (MetS) is a common global disorder that predisposes to both Type 2 diabetes mellitus (T2DM) and cardiovascular disease (ASCVD). Adipose tissue (AT) contributes significantly to increased inflammation and insulin resistance (IR) in MetS which appear to be the crucial underpinnings of MetS. Compared to macrophages and lymphocytes in human subcutaneous AT (SAT), there is sparse data on the role of other immune cells, especially eosinophils (EOS). In this study, we investigated the abundance of EOS in the SAT of 19 patients with MetS without diabetes, ASCVD, smoking or any inflammatory condition, and matched controls. Methods: SAT EOS were quantified by immunohistochemistry. Results: Both circulating and SAT EOS were significantly increased 2-fold in MetS and correlated with each other. Circulating EOS correlated significantly with triglycerides (TG), high-sensitivity CRP, leptin, and IL-6. SAT EOS correlated significantly with plasma glucose, TG, FFA, adipose-IR, leptin, IL-6, endotoxin, chemerin and inversely with adiponectin. They also correlated with SAT markers of fibrosis: collagen and Sirius red staining of SAT. Conclusion: We make the novel and seminal observation that eosinophils are increased in SAT of MetS patients, and are associated with the pro-inflammatory state. Hence, in humans, they appear to contribute to the dysregulation of SAT biology in MetS.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StatePublished - Jan 1 2019

Keywords

  • Eosinophils
  • Fibrosis
  • Inflammation
  • Metabolic Syndrome
  • Subcutaneous adipose tissue

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Increased eosinophils in adipose tissue of metabolic syndrome'. Together they form a unique fingerprint.

  • Cite this