TY - JOUR
T1 - Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
AU - Lo, Janet
AU - Abbara, Suhny
AU - Rocha-Filho, Jose A.
AU - Shturman, Leon
AU - Wei, Jeffrey
AU - Grinspoon, Steven K.
PY - 2010/8/24
Y1 - 2010/8/24
N2 - Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (ρ = 0.76, P < 0.0001), fasting glucose (ρ = 0.41, P = 0.001) and insulin (ρ = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.
AB - Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (ρ = 0.76, P < 0.0001), fasting glucose (ρ = 0.41, P = 0.001) and insulin (ρ = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.
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U2 - 10.1097/QAD.0b013e32833c055a
DO - 10.1097/QAD.0b013e32833c055a
M3 - Article
C2 - 20588167
AN - SCOPUS:77955425184
SN - 0269-9370
VL - 24
SP - 2127
EP - 2130
JO - AIDS
JF - AIDS
IS - 13
ER -