Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma

Anice E. Thigpen, Kristine M. Cala, Joseph M. Guileyardo, Kyle H. Molberg, John D. McConnell, David W. Russell

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.

Original languageEnglish (US)
Pages (from-to)975-981
Number of pages7
JournalJournal of Urology
Volume155
Issue number3
DOIs
StatePublished - Mar 1996

Keywords

  • neoplasm metastasis
  • prostatic neoplasms
  • transcription factors

ASJC Scopus subject areas

  • Urology

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