Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma

Anice E. Thigpen, Kristine M. Cala, Joseph M. Guileyardo, Kyle H. Molberg, John D. McConnell, David W. Russell

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.

Original languageEnglish (US)
Pages (from-to)975-981
Number of pages7
JournalJournal of Urology
Volume155
Issue number3
DOIs
StatePublished - Mar 1996

Fingerprint

Adenocarcinoma
RNA
Growth
Prostate
Stromal Cells
Ovarian Neoplasms
Neoplasms
Transcription Factors
Lymph Nodes
Epithelial Cells
Breast Neoplasms
Neoplasm Metastasis
Gene Expression
Polymerase Chain Reaction
DNA
Genes

Keywords

  • neoplasm metastasis
  • prostatic neoplasms
  • transcription factors

ASJC Scopus subject areas

  • Urology

Cite this

Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma. / Thigpen, Anice E.; Cala, Kristine M.; Guileyardo, Joseph M.; Molberg, Kyle H.; McConnell, John D.; Russell, David W.

In: Journal of Urology, Vol. 155, No. 3, 03.1996, p. 975-981.

Research output: Contribution to journalArticle

Thigpen, Anice E. ; Cala, Kristine M. ; Guileyardo, Joseph M. ; Molberg, Kyle H. ; McConnell, John D. ; Russell, David W. / Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma. In: Journal of Urology. 1996 ; Vol. 155, No. 3. pp. 975-981.
@article{62bf5640e4c24d25bbf32c1011d9751b,
title = "Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma",
abstract = "Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.",
keywords = "neoplasm metastasis, prostatic neoplasms, transcription factors",
author = "Thigpen, {Anice E.} and Cala, {Kristine M.} and Guileyardo, {Joseph M.} and Molberg, {Kyle H.} and McConnell, {John D.} and Russell, {David W.}",
year = "1996",
month = "3",
doi = "10.1016/S0022-5347(01)66361-4",
language = "English (US)",
volume = "155",
pages = "975--981",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma

AU - Thigpen, Anice E.

AU - Cala, Kristine M.

AU - Guileyardo, Joseph M.

AU - Molberg, Kyle H.

AU - McConnell, John D.

AU - Russell, David W.

PY - 1996/3

Y1 - 1996/3

N2 - Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.

AB - Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.

KW - neoplasm metastasis

KW - prostatic neoplasms

KW - transcription factors

UR - http://www.scopus.com/inward/record.url?scp=0030062287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030062287&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(01)66361-4

DO - 10.1016/S0022-5347(01)66361-4

M3 - Article

C2 - 8583621

AN - SCOPUS:0030062287

VL - 155

SP - 975

EP - 981

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3

ER -