Abstract
Purpose: We isolated genes whose expression differs between normal and malignant prostate. Materials and Methods: Differential display polymerase chain reactions revealed a messenger ribonucleic acid (mRNA) with higher expression in prostatic adenocarcinoma versus age matched normal tissue. Deoxyribonucleic acid sequencing identified this mRNA as the product of the early growth response-1 gene. Results: Early growth response-1 mRNA levels were elevated in 12 of 12 intraprostatic adenocarcinomas but not in breast or ovarian cancers, or in rapidly dividing rat ventral prostate cells. Early growth response-1 mRNA was detected in epithelial and stromal cells at tumor margins but not in lymph node metastases. Conclusions: Early growth response- 1, a nuclear transcription factor, is implicated in the growth and invasion of intraprostatic cancers.
Original language | English (US) |
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Pages (from-to) | 975-981 |
Number of pages | 7 |
Journal | Journal of Urology |
Volume | 155 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1996 |
Keywords
- neoplasm metastasis
- prostatic neoplasms
- transcription factors
ASJC Scopus subject areas
- Urology