Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines

Akane Shikata, Tohru Sugimoto, Hajime Hosoi, Yasuhiro Sotozono, Takuma Shikata, Tadashi Sawada, Luis F. Parada

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Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalJapanese Journal of Cancer Research
Issue number2
StatePublished - Feb 1994



  • Neuroblastoma
  • N‐myc
  • trk
  • γ‐Interferon

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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