Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines

Akane Shikata; Tohru Sugimoto; Hajime Hosoi; Yasuhiro Sotozono; Takuma Shikata; Tadashi Sawada; Luis F. Parada

doi:10.1111/j.1349-7006.1994.tb02070.x

Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines

Akane Shikata, Tohru Sugimoto, Hajime Hosoi, Yasuhiro Sotozono, Takuma Shikata, Tadashi Sawada, Luis F. Parada

Developmental Biology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	85
Issue number	2
DOIs	https://doi.org/10.1111/j.1349-7006.1994.tb02070.x
State	Published - Feb 1994

Keywords

Neuroblastoma
N‐myc
trk
γ‐Interferon

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1111/j.1349-7006.1994.tb02070.x

Cite this

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abstract = "Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.",

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AU - Shikata, Akane

AU - Sugimoto, Tohru

AU - Hosoi, Hajime

AU - Sotozono, Yasuhiro

AU - Shikata, Takuma

AU - Sawada, Tadashi

AU - Parada, Luis F.

PY - 1994/2

Y1 - 1994/2

N2 - Three human neuroblastoma cell lines were examined to determine the effect of recombinant γ‐interferon (IFN‐γ) treatment on the expression of trk proto‐oncogene. Increased levels of trk proto‐oncogene mRNA were observed in two neuroblastoma cell lines (KP‐N‐RT and KP‐N‐SI(FA)) after IFN‐γ treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time‐ and dose‐dependent manner. The decreased level of N‐myc mRNA after IFN‐γ‐treatment in KP‐N‐RT was inversely correlated with trk mRNA. Our results suggest that IFN‐γ can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.

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KW - γ‐Interferon

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Increased Expression of trk Proto‐oncogene by γ‐Interferon in Human Neuroblastoma Cell Lines

Abstract

Keywords

ASJC Scopus subject areas

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