Increased frequency of pre-germinal center b cells and plasma cell precursors in the blood of children with systemic lupus erythematosus

E. Arce, D. G. Jackson, M. A. Gill, L. B. Bennett, J. Banchereau, V. Pascual

Research output: Contribution to journalArticle

204 Scopus citations

Abstract

We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD+ CD38+ centerin+), and a plasma cell precursor subset (CD20-CD19+/lowCD27+/++CD38++). In SLE patients, naive and memory B cells (CD20+CD38-) are ∼90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded, independently of disease activity and modality of therapy. Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients. Thus, SLE is associated with major blood B cell subset alterations.

Original languageEnglish (US)
Pages (from-to)2361-2369
Number of pages9
JournalJournal of Immunology
Volume167
Issue number4
DOIs
StatePublished - Aug 15 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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