Increased incidence and clinical correlation of persistently abnormal technetium pyrophosphate myocardial scintigrams following acute myocardial infarction in patients with diabetes mellitus

Pascal Nicod, Samuel E. Lewis, James C. Corbett, Maximilian Buja, Gene Henderson, Philip Raskin, Robert E. Rude, James T. Willerson

Research output: Contribution to journalArticle

12 Scopus citations


"Persistently abnormal" technetium-99m stannous pyrophosphate myocardial scintigrams (PPi+) appear to be associated with a relatively poor prognosis after acute myocardial infarction (AMI). To assess the incidence and implications of PPi+, we performed a retrospective analysis in 29 patients with and 25 patients without diabetes mellitus who had abnormal myocardial scintigrams within 4 days of AMI and who had follow-up scintigrams at least 3 months after hospital discharge. There were no significant differences between patients with and without diabetes as regards age, incidence of transmural or nontransmural AMI, or degree of left ventricular dysfunction after AMI. Persistently abnormal PPi+ occurred more commonly in patients with diabetes than in nondiabetic patients (18 of 29, 62%, compared to 3 of 25, 12%; p < 0.001). Patients with chronic PPi+ had more frequent cardiac complications following hospital discharge (p < 0.005) including death, recurrent AMI, unstable angina, and intractable congestive heart failure. Postmortem analysis in two patients with diabetes and chronic PPi+ revealed marked myocytolysis. Thus, patients with diabetes mellitus have an increased incidence of post-AMI "persistently abnormal" technetium (PPi+) scintigrams and relatively poor prognosis following myocardial infarction.

Original languageEnglish (US)
Pages (from-to)822-829
Number of pages8
JournalAmerican Heart Journal
Issue number5
Publication statusPublished - 1982


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this