TY - JOUR
T1 - Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma
AU - Wax, M. B.
AU - Barrett, D. A.
AU - Pestronk, A.
N1 - Funding Information:
From the Departments of Ophthalmology and Visual Science (Drs. Wax and Barrett), Neurology (Drs. Barrett and Pestronk), Neurological Surgery (Dr. Barrett), and Pathology (Dr. Pestronk), Washington University School of Medicine, St. Louis, Missouri. This study was supported by National Institutes of Health grant EY06810 (Dr. Wax), National Institutes of Health Clinical Research Center grant RR0036 (Dr. Pestronk), and National Institutes of Health Alzheimer Disease Research Center grant SP50A605681 (Dr. Pestronk).
PY - 1994
Y1 - 1994
N2 - We assessed the incidence of paraproteins and autoantibodies in 44 patients (mean age, 65.3 ± 1.9 years) with normal-pressure glaucoma and 41 patients (mean age, 68.8 ± 1.8 years) with primary open-angle glaucoma. Serum monoclonal proteins occurred more often (P = .0047) in patients with normal-pressure glaucoma (eight of 44, 18%) than in control subjects with primary open-angle glaucoma (zero of 41, 0%). Autoantibodies to extractable nuclear antigens, most often Sjogren's syndrome A antigen (SSA[Ro]), were also found more frequently (P = .0022) in patients with normal-pressure glaucoma (13 of 44, 30%) than in control subjects (one of 41, 2%). Paraproteins and autoantibodies to extractable nuclear antigens generally occurred in different patients with an overall incidence of 20 of 44 (45%) patients with normal-pressure glaucoma. In contrast, no significant difference in the incidence of antinuclear antibodies existed between the groups. These findings suggest that humoral immune mechanisms may have a role in the pathogenesis of optic neuropathy in patients with normal-pressure glaucoma.
AB - We assessed the incidence of paraproteins and autoantibodies in 44 patients (mean age, 65.3 ± 1.9 years) with normal-pressure glaucoma and 41 patients (mean age, 68.8 ± 1.8 years) with primary open-angle glaucoma. Serum monoclonal proteins occurred more often (P = .0047) in patients with normal-pressure glaucoma (eight of 44, 18%) than in control subjects with primary open-angle glaucoma (zero of 41, 0%). Autoantibodies to extractable nuclear antigens, most often Sjogren's syndrome A antigen (SSA[Ro]), were also found more frequently (P = .0022) in patients with normal-pressure glaucoma (13 of 44, 30%) than in control subjects (one of 41, 2%). Paraproteins and autoantibodies to extractable nuclear antigens generally occurred in different patients with an overall incidence of 20 of 44 (45%) patients with normal-pressure glaucoma. In contrast, no significant difference in the incidence of antinuclear antibodies existed between the groups. These findings suggest that humoral immune mechanisms may have a role in the pathogenesis of optic neuropathy in patients with normal-pressure glaucoma.
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U2 - 10.1016/S0002-9394(14)70059-5
DO - 10.1016/S0002-9394(14)70059-5
M3 - Article
C2 - 8172259
AN - SCOPUS:0028332131
SN - 0002-9394
VL - 117
SP - 561
EP - 568
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -