Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid

S. Usuki, T. Saitoh, T. Sawamura, N. Suzuki, S. Shigemitsu, Masashi Yanagisawa, K. Goto, H. Onda, M. Fujino, T. Masaki

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The concentration of endothelin-1 (ET-1) in plasma and amniotic fluid from normal pregnant women was determined by a sensitive sandwich-enzyme immunoassay system, established recently. The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 ± 0.02 pmol/1, n = 45) being significantly (p < 0.05) higher after 29 weeks of gestation than those (0.32 ± 0.01 pmol/1, n = 30) before 28 weeks of gestation. The plasma ET-1 level during labor pain was significantly higher (0.59 ± 0.06 pmol/1, n = 10) than that (0.40 ± 0.02 pmol/1, n = 45) in the 3rd trimester of pregnancy without labor pain (p < 0.02). Moreover, a high level of ET-1 (17.38 ± 0.25 pmol/1, n = 18) was detected in amniotic fluid on term delivery. The ET-1 level in amniotic fluid was significantly higher than the levels in maternal and umbilical cord plasma (p < 0.001 and p < 0.001, respectively). After delivery the maternal ET-1 level decreased gradually and 2 day postpartum ET-1 levels reached the normal non-pregnant level. Taken together, these results suggest that ET-1 might play an important role in uterine contraction and also participate in labor.

Original languageEnglish (US)
Pages (from-to)85-97
Number of pages13
JournalGynecological Endocrinology
Volume4
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Labor Pain
Endothelin-1
Amniotic Fluid
Mothers
Pregnancy
Pregnancy Trimesters
Uterine Contraction
Umbilical Cord
Immunoenzyme Techniques
Postpartum Period
Pregnant Women

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynecology

Cite this

Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid. / Usuki, S.; Saitoh, T.; Sawamura, T.; Suzuki, N.; Shigemitsu, S.; Yanagisawa, Masashi; Goto, K.; Onda, H.; Fujino, M.; Masaki, T.

In: Gynecological Endocrinology, Vol. 4, No. 2, 1990, p. 85-97.

Research output: Contribution to journalArticle

Usuki, S. ; Saitoh, T. ; Sawamura, T. ; Suzuki, N. ; Shigemitsu, S. ; Yanagisawa, Masashi ; Goto, K. ; Onda, H. ; Fujino, M. ; Masaki, T. / Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid. In: Gynecological Endocrinology. 1990 ; Vol. 4, No. 2. pp. 85-97.
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abstract = "The concentration of endothelin-1 (ET-1) in plasma and amniotic fluid from normal pregnant women was determined by a sensitive sandwich-enzyme immunoassay system, established recently. The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 ± 0.02 pmol/1, n = 45) being significantly (p < 0.05) higher after 29 weeks of gestation than those (0.32 ± 0.01 pmol/1, n = 30) before 28 weeks of gestation. The plasma ET-1 level during labor pain was significantly higher (0.59 ± 0.06 pmol/1, n = 10) than that (0.40 ± 0.02 pmol/1, n = 45) in the 3rd trimester of pregnancy without labor pain (p < 0.02). Moreover, a high level of ET-1 (17.38 ± 0.25 pmol/1, n = 18) was detected in amniotic fluid on term delivery. The ET-1 level in amniotic fluid was significantly higher than the levels in maternal and umbilical cord plasma (p < 0.001 and p < 0.001, respectively). After delivery the maternal ET-1 level decreased gradually and 2 day postpartum ET-1 levels reached the normal non-pregnant level. Taken together, these results suggest that ET-1 might play an important role in uterine contraction and also participate in labor.",
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