TY - JOUR
T1 - Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid
AU - Usuki, S.
AU - Saitoh, T.
AU - Sawamura, T.
AU - Suzuki, N.
AU - Shigemitsu, S.
AU - Yanagisawa, Masashi
AU - Goto, K.
AU - Onda, H.
AU - Fujino, M.
AU - Masaki, T.
N1 - Funding Information:
This work was supported in part by grants from the University of Tsukuba Project Research, the University of Tsukuba Special Project Research on Metabolism and the Ministry of Education, Science and Culture ofJapan.
PY - 1990
Y1 - 1990
N2 - The concentration of endothelin-1 (ET-1) in plasma and amniotic fluid from normal pregnant women was determined by a sensitive sandwich-enzyme immunoassay system, established recently. The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 ± 0.02 pmol/1, n = 45) being significantly (p < 0.05) higher after 29 weeks of gestation than those (0.32 ± 0.01 pmol/1, n = 30) before 28 weeks of gestation. The plasma ET-1 level during labor pain was significantly higher (0.59 ± 0.06 pmol/1, n = 10) than that (0.40 ± 0.02 pmol/1, n = 45) in the 3rd trimester of pregnancy without labor pain (p < 0.02). Moreover, a high level of ET-1 (17.38 ± 0.25 pmol/1, n = 18) was detected in amniotic fluid on term delivery. The ET-1 level in amniotic fluid was significantly higher than the levels in maternal and umbilical cord plasma (p < 0.001 and p < 0.001, respectively). After delivery the maternal ET-1 level decreased gradually and 2 day postpartum ET-1 levels reached the normal non-pregnant level. Taken together, these results suggest that ET-1 might play an important role in uterine contraction and also participate in labor.
AB - The concentration of endothelin-1 (ET-1) in plasma and amniotic fluid from normal pregnant women was determined by a sensitive sandwich-enzyme immunoassay system, established recently. The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 ± 0.02 pmol/1, n = 45) being significantly (p < 0.05) higher after 29 weeks of gestation than those (0.32 ± 0.01 pmol/1, n = 30) before 28 weeks of gestation. The plasma ET-1 level during labor pain was significantly higher (0.59 ± 0.06 pmol/1, n = 10) than that (0.40 ± 0.02 pmol/1, n = 45) in the 3rd trimester of pregnancy without labor pain (p < 0.02). Moreover, a high level of ET-1 (17.38 ± 0.25 pmol/1, n = 18) was detected in amniotic fluid on term delivery. The ET-1 level in amniotic fluid was significantly higher than the levels in maternal and umbilical cord plasma (p < 0.001 and p < 0.001, respectively). After delivery the maternal ET-1 level decreased gradually and 2 day postpartum ET-1 levels reached the normal non-pregnant level. Taken together, these results suggest that ET-1 might play an important role in uterine contraction and also participate in labor.
UR - http://www.scopus.com/inward/record.url?scp=0025327722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025327722&partnerID=8YFLogxK
U2 - 10.3109/09513599009012325
DO - 10.3109/09513599009012325
M3 - Article
C2 - 2204252
AN - SCOPUS:0025327722
SN - 0951-3590
VL - 4
SP - 85
EP - 97
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 2
ER -