Increased Modularity of Resting State Networks Supports Improved Narrative Production in Aphasia Recovery

E. Susan Duncan, Steven L. Small

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The networks that emerge in the analysis of resting state functional magnetic resonance imaging (rsfMRI) data are believed to reflect the intrinsic organization of the brain. One key property of such complex biological networks is modularity, a measure of community structure. This topological characteristic changes in neurological disease and recovery. Nineteen subjects with language disorders after stroke (aphasia) underwent neuroimaging and behavioral assessment at multiple time points before (baseline) and after an imitation-based therapy. Language was assessed with a narrative production task. Group independent component analysis was performed on the rsfMRI data to identify resting state networks (RSNs). For each participant and each rsfMRI acquisition, we constructed a graph comprising all RSNs. We assigned nodal community based on a region's RSN membership, calculated the modularity score, and then correlated changes in modularity and therapeutic gains on the narrative task. We repeated this comparison controlling for pretherapy performance and using a community structure not based on RSN membership. Increased RSN modularity was positively correlated with improvement on the narrative task immediately post-therapy. This finding remained significant when controlling for pretherapy performance. There were no significant findings for network modularity and behavior when nodal community was assigned without consideration of RSN membership. We interpret these findings as support for the adaptive role of network segregation in behavioral improvement in aphasia therapy. This has important clinical implications for the targeting of noninvasive brain stimulation in poststroke remediation and suggests potential for further insight into the processes underlying such changes through computational modeling.

Original languageEnglish (US)
Pages (from-to)524-529
Number of pages6
JournalBrain Connectivity
Volume6
Issue number7
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

Aphasia
Magnetic Resonance Imaging
Language Disorders
Brain
Therapeutics
Neuroimaging
Language
Stroke

Keywords

  • aphasia
  • functional neuroimaging
  • graph theory
  • network analysis
  • rehabilitation
  • resting state
  • speech-language pathology
  • stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increased Modularity of Resting State Networks Supports Improved Narrative Production in Aphasia Recovery. / Duncan, E. Susan; Small, Steven L.

In: Brain Connectivity, Vol. 6, No. 7, 01.09.2016, p. 524-529.

Research output: Contribution to journalArticle

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