Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy

Kern Wildenthal; Edward A. Mueller

doi:10.1038/249478a0

Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy

Kern Wildenthal, Edward A. Mueller

Internal Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

SEVERAL types of hormonal or mechanical stimuli may cause cardiac hypertrophy. In many instances, when the stimulus is removed the heart rapidly regresses toward its original size. The cellular mechanism(s) by which this net cardiac catabolism and reduction of myocardial protein mass might be mediated have not been defined. One possibility might be an increase in the activity of intracellular proteolytic enzymes; accordingly, we have investigated the activity of cathepsin D, a lysosomal enzyme that is the major acid proteinase in the heart.

Original language	English (US)
Pages (from-to)	478-479
Number of pages	2
Journal	Nature
Volume	249
Issue number	5456
DOIs	https://doi.org/10.1038/249478a0
State	Published - 1974

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title = "Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy",

abstract = "SEVERAL types of hormonal or mechanical stimuli may cause cardiac hypertrophy. In many instances, when the stimulus is removed the heart rapidly regresses toward its original size. The cellular mechanism(s) by which this net cardiac catabolism and reduction of myocardial protein mass might be mediated have not been defined. One possibility might be an increase in the activity of intracellular proteolytic enzymes; accordingly, we have investigated the activity of cathepsin D, a lysosomal enzyme that is the major acid proteinase in the heart.",

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AU - Mueller, Edward A.

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AB - SEVERAL types of hormonal or mechanical stimuli may cause cardiac hypertrophy. In many instances, when the stimulus is removed the heart rapidly regresses toward its original size. The cellular mechanism(s) by which this net cardiac catabolism and reduction of myocardial protein mass might be mediated have not been defined. One possibility might be an increase in the activity of intracellular proteolytic enzymes; accordingly, we have investigated the activity of cathepsin D, a lysosomal enzyme that is the major acid proteinase in the heart.

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Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy

Abstract

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