Increased nerve conduction in diabetics after a year of improved glucoregulation

Albert L. Ehle, Philip Raskin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We studied median, ulnar and peroneal motor nerve conduction velocity (NCV) and median sensory action potential (SAP) latency and amplitude in 18 insulin-dependent diabetic patients who were begun on a continuous subcutaneous insulin infusion (CSII) program. With institution of this therapy, significant decreases in mean blood glucose and glycosylated hemoglobin occurred. After 12 months of CSII treatment, median, peroneal, and ulnar motor NCVs all increased significantly. The average NCV increase was 2.5 m/s. Median SAP amplitude and latency did not significantly change. In a second group of 12 diabetic patients with the same mean age and comparable initial NCV and SAP measures, no significant changes in motor NCVs or SAPs occurred after 12 months of conventional insulin treatment. These results indicated the need for further long-term studies of the role of strict glucose control in the prevention of diabetic neuropathy.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of the Neurological Sciences
Volume74
Issue number2-3
DOIs
StatePublished - 1986

Fingerprint

Neural Conduction
Insulin
Action Potentials
Subcutaneous Infusions
Peroneal Nerve
Diabetic Neuropathies
Glycosylated Hemoglobin A
Blood Glucose
Therapeutics
Glucose

Keywords

  • Diabetes
  • Nerve conduction
  • Neuropathy

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Increased nerve conduction in diabetics after a year of improved glucoregulation. / Ehle, Albert L.; Raskin, Philip.

In: Journal of the Neurological Sciences, Vol. 74, No. 2-3, 1986, p. 191-197.

Research output: Contribution to journalArticle

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