Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage

Bruce M. McCormack, Dale M. Swift, Margarett T. Hegemann, Robert A. Solomon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalBrain Research
Volume382
Issue number2
DOIs
StatePublished - Sep 24 1986

Keywords

  • locus coeruleus
  • norpinephrine
  • subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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