Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar, Harold B. Stull, Lary J. Kilton, Uriel Bachrach

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.

Original languageEnglish (US)
Pages (from-to)696-698
Number of pages3
JournalNature
Volume262
Issue number5570
DOIs
StatePublished - 1976

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Murine Sarcoma Viruses
Ornithine Decarboxylase
Hepatocellular Carcinoma
Rous sarcoma virus
Ornithine
Putrescine
Enzymes
Neuroblastoma
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Increased ornithine decarboxylase activity in murine sarcoma virus infected cells. / Gazdar, Adi F.; Stull, Harold B.; Kilton, Lary J.; Bachrach, Uriel.

In: Nature, Vol. 262, No. 5570, 1976, p. 696-698.

Research output: Contribution to journalArticle

Gazdar, Adi F. ; Stull, Harold B. ; Kilton, Lary J. ; Bachrach, Uriel. / Increased ornithine decarboxylase activity in murine sarcoma virus infected cells. In: Nature. 1976 ; Vol. 262, No. 5570. pp. 696-698.
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