Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar; Harold B. Stull; Lary J. Kilton; Uriel Bachrach

doi:10.1038/262696a0

Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar, Harold B. Stull, Lary J. Kilton, Uriel Bachrach

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Abstract

POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation^1,2, and the rate at which it proceeds ³ is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth^4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells ^3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones⁶. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change⁸.

Original language	English (US)
Pages (from-to)	696-698
Number of pages	3
Journal	Nature
Volume	262
Issue number	5570
DOIs	https://doi.org/10.1038/262696a0
State	Published - Dec 1 1976

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title = "Increased ornithine decarboxylase activity in murine sarcoma virus infected cells",

abstract = "POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.",

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T1 - Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

AU - Gazdar, Adi F.

AU - Stull, Harold B.

AU - Kilton, Lary J.

AU - Bachrach, Uriel

PY - 1976/12/1

Y1 - 1976/12/1

N2 - POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.

AB - POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.

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Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

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