Increased ornithine decarboxylase activity in murine sarcoma virus infected cells

Adi F. Gazdar, Harold B. Stull, Lary J. Kilton, Uriel Bachrach

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

POLYAMINE biosynthesis is one of the earliest events occurring during cellular proliferation1,2, and the rate at which it proceeds 3 is limited by ornithine decarboxylase (ODC), an enzyme which catalyses the formation of putrescine from ornithine. ODC levels are low, but stable, in resting cells, and a large increase in activity occurs rapidly after the onset of growth4,5. Elevated ODC levels occur in certain tumour cells, including hepatoma, neuroblastoma and SV40-transformed cells 3-7. Fast growing hepatomas have higher enzyme levels than slow growing ones6. During Rous sarcoma virus (RSV) transformation, elevation of ODC levels precedes morphological change8.

Original languageEnglish (US)
Pages (from-to)696-698
Number of pages3
JournalNature
Volume262
Issue number5570
DOIs
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • General

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