Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β

Ishtiaq Qadri, Mahua Choudhury, Shaikh Mizanoor Rahman, Trina A. Knotts, Rachel C. Janssen, Jerome Schaack, Mieko Iwahashi, Livia Puljak, Francis R. Simon, Gordan Kilic, Gregory Fitz, Jacob E. Friedman

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Chronic hepatitis C virus (HCV) infection increases the risk of type 2 diabetes and hepatic steatosis. Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. Conclusion: Increased CCAAT/enhancer-binding protein β (C/EBPβ) and nonstructural component 5A (NS5A) are essential components for increased gluconeogenesis. Significance: NS5A and C/EBPβ may possibly be considered as a new pharmacological target during HCV infection.

Original languageEnglish (US)
Pages (from-to)37340-37351
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Qadri, I., Choudhury, M., Rahman, S. M., Knotts, T. A., Janssen, R. C., Schaack, J., Iwahashi, M., Puljak, L., Simon, F. R., Kilic, G., Fitz, G., & Friedman, J. E. (2012). Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β. Journal of Biological Chemistry, 287(44), 37340-37351. https://doi.org/10.1074/jbc.M112.384743