Increased platelet distribution width predicts poor prognosis in melanoma patients

Na Li, Zhiyong Diao, Xiaoyi Huang, Ye Niu, Tiemin Liu, Zhi Ping Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386-4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.

Original languageEnglish (US)
Article number2970
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Melanoma
Blood Platelets
Survival
Normal Distribution
Hematologic Tests
Neoplasms
Regression Analysis
Confidence Intervals
Neoplasm Metastasis

ASJC Scopus subject areas

  • General

Cite this

Increased platelet distribution width predicts poor prognosis in melanoma patients. / Li, Na; Diao, Zhiyong; Huang, Xiaoyi; Niu, Ye; Liu, Tiemin; Liu, Zhi Ping; Wang, Rui Tao; Yu, Kai Jiang.

In: Scientific Reports, Vol. 7, No. 1, 2970, 01.12.2017.

Research output: Contribution to journalArticle

Li, Na ; Diao, Zhiyong ; Huang, Xiaoyi ; Niu, Ye ; Liu, Tiemin ; Liu, Zhi Ping ; Wang, Rui Tao ; Yu, Kai Jiang. / Increased platelet distribution width predicts poor prognosis in melanoma patients. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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abstract = "Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6{\%}) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95{\%} confidence interval [CI], 1.386-4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.",
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AU - Li, Na

AU - Diao, Zhiyong

AU - Huang, Xiaoyi

AU - Niu, Ye

AU - Liu, Tiemin

AU - Liu, Zhi Ping

AU - Wang, Rui Tao

AU - Yu, Kai Jiang

PY - 2017/12/1

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N2 - Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386-4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.

AB - Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386-4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.

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