TY - JOUR
T1 - Increased risk of hip fracture among Japanese hemodialysis patients
AU - Wakasugi, Minako
AU - Kazama, Junichiro James
AU - Taniguchi, Masatomo
AU - Wada, Atsushi
AU - Iseki, Kunitoshi
AU - Tsubakihara, Yoshiharu
AU - Narita, Ichiei
N1 - Funding Information:
These data were presented in part at the annual meeting of the American Society of Nephrology, December 15–19, 2011, Philadelphia, PA. Data were obtained with the permission of the Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy. We used the standard analysis file (JRDR-09001) for this study. The opinions reflected in this manuscript are those of the authors alone and do not reflect an official position of the Japanese Society for Dialysis Therapy. This study was supported in part by a Grant-in-Aid for Progressive Renal Diseases Research, Research on Intractable Disease, from the Ministry of Health, Labor, and Welfare of Japan.
PY - 2013/5
Y1 - 2013/5
N2 - Incidence of hip fracture in dialysis patients is significantly higher than that in the general population. As information is lacking about Asian dialysis patients, we compared the incidence of hip fracture in hemodialysis patients with that in the general population in Japan. We conducted a retrospective cohort study using panel data from the Japanese Society for Dialysis Therapy registry. The study included patients without history of hip fracture who received hemodialysis three times per week as of December 31, 2007. We compared the observed number of hip fractures to the expected number derived from a national survey, and calculated standardized incidence ratios (SIRs) and the incidence rate difference. Subgroup analysis was performed according to vintage and diabetic status. During the one-year study period, 1,437 hip fractures were recorded in the 128,141 hemodialysis patients (61.9 % male). The overall incidence was 7.57 and 17.43 per 1,000 person-years in men and women, respectively. The SIRs for male and female patients were 6.2 [95 % confidence interval (CI) 5.7-6.8] and 4.9 (95 % CI 4.6-5.3) compared to the general population, and remained nearly constant until 16 years vintage, but increased steeply thereafter. The incidence rate difference of hip fracture increased with age. The SIRs for diabetics of both genders were higher than those for non-diabetics. Our study provides additional evidence that hip fracture risk among Asian dialysis patients is also significantly higher than in the general population.
AB - Incidence of hip fracture in dialysis patients is significantly higher than that in the general population. As information is lacking about Asian dialysis patients, we compared the incidence of hip fracture in hemodialysis patients with that in the general population in Japan. We conducted a retrospective cohort study using panel data from the Japanese Society for Dialysis Therapy registry. The study included patients without history of hip fracture who received hemodialysis three times per week as of December 31, 2007. We compared the observed number of hip fractures to the expected number derived from a national survey, and calculated standardized incidence ratios (SIRs) and the incidence rate difference. Subgroup analysis was performed according to vintage and diabetic status. During the one-year study period, 1,437 hip fractures were recorded in the 128,141 hemodialysis patients (61.9 % male). The overall incidence was 7.57 and 17.43 per 1,000 person-years in men and women, respectively. The SIRs for male and female patients were 6.2 [95 % confidence interval (CI) 5.7-6.8] and 4.9 (95 % CI 4.6-5.3) compared to the general population, and remained nearly constant until 16 years vintage, but increased steeply thereafter. The incidence rate difference of hip fracture increased with age. The SIRs for diabetics of both genders were higher than those for non-diabetics. Our study provides additional evidence that hip fracture risk among Asian dialysis patients is also significantly higher than in the general population.
KW - General population
KW - Hemodialysis
KW - Hip fracture
KW - Standardized incidence ratio
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U2 - 10.1007/s00774-012-0411-z
DO - 10.1007/s00774-012-0411-z
M3 - Article
C2 - 23292163
AN - SCOPUS:84878574579
SN - 0914-8779
VL - 31
SP - 315
EP - 321
JO - Journal of Bone and Mineral Metabolism
JF - Journal of Bone and Mineral Metabolism
IS - 3
ER -