Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution

David Q. Rich, Murray A. Mittleman, Mark S. Link, Joel Schwartz, Heike Luttmann-Gibson, Paul J. Catalano, Frank E. Speizer, Diane R. Gold, Douglas W. Dockery

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objectives: We reported previously that 24-hr moving average ambient air pollution concentrations were positively associated with ventricular arrhythmias detected by implantable cardioverter defibrillators (ICDs). ICDs also detect paroxysmal atrial fibrillation episodes (PAF) that result in rapid ventricular rates. In this same cohort of ICD patients, we assessed the association between ambient air pollution and episodes of PAF. Design: We performed a case-crossover study. Participants: Patients who lived in the Boston, Massachusetts, metropolitan area and who had ICDs implanted between June 1995 and December 1999 (n = 203) were followed until July 2002. Evaluations/Measurements: We used conditional logistic regression to explore the association between community air pollution and 91 electrophysiologist-confirmed episodes of PAF among 29 subjects. Results: We found a statistically significant positive association between episodes of PAF and increased ozone concentration (22 ppb) in the hour before the arrhythmia (odds ratio = 2.08; 95% confidence interval = 1.22, 3.54; p = 0.001). The risk estimate for a longer (24-hr) moving average was smaller, thus suggesting an immediate effect. Positive but not statistically significant risks were associated with fine particles, nitrogen dioxide, and black carbon. Conclusions: Increased ambient O3 pollution was associated with increased risk of episodes of rapid ventricular response due to PAF, thereby suggesting that community air pollution may be a precipitant of these events.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalEnvironmental Health Perspectives
Volume114
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Air Pollution
Atrial Fibrillation
Implantable Defibrillators
Cardiac Arrhythmias
Soot
Nitrogen Dioxide
Ozone
Cross-Over Studies
Logistic Models
Odds Ratio
Confidence Intervals

Keywords

  • Air pollution
  • Arrhythmias
  • Case-crossover
  • Epidemiology
  • Fibrillation
  • Ozone

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Rich, D. Q., Mittleman, M. A., Link, M. S., Schwartz, J., Luttmann-Gibson, H., Catalano, P. J., ... Dockery, D. W. (2006). Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution. Environmental Health Perspectives, 114(1), 120-123. https://doi.org/10.1289/ehp.8371

Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution. / Rich, David Q.; Mittleman, Murray A.; Link, Mark S.; Schwartz, Joel; Luttmann-Gibson, Heike; Catalano, Paul J.; Speizer, Frank E.; Gold, Diane R.; Dockery, Douglas W.

In: Environmental Health Perspectives, Vol. 114, No. 1, 01.01.2006, p. 120-123.

Research output: Contribution to journalArticle

Rich, DQ, Mittleman, MA, Link, MS, Schwartz, J, Luttmann-Gibson, H, Catalano, PJ, Speizer, FE, Gold, DR & Dockery, DW 2006, 'Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution', Environmental Health Perspectives, vol. 114, no. 1, pp. 120-123. https://doi.org/10.1289/ehp.8371
Rich, David Q. ; Mittleman, Murray A. ; Link, Mark S. ; Schwartz, Joel ; Luttmann-Gibson, Heike ; Catalano, Paul J. ; Speizer, Frank E. ; Gold, Diane R. ; Dockery, Douglas W. / Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 1. pp. 120-123.
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