Abstract
In mammals, GABAergic projections from the substantia nigra reticulata to the superior colliculus provide tonic inhibition to tectal neurons involved in the generation of saccades. Dysfunction of this pathway has been shown to produce saccadic "distractibility" in the experimental monkey. In two oculomotor paradigms, control of saccadic eye movements was tested in chronic schizophrenic patients with (n = 18) and without (n = 16) tardive dyskinesia (TD) and normal controls (n = 8). The three groups were matched by mean age; the TD and non-TD patient groups had similar duration of illness, benztropine and chlorpromazine equivalent doses and educational levels. A twofold increase in saccadic distractibility was observed in TD compared to non-TD schizophrenic patients, and both patient groups demonstrated a greater saccadic distractibility than normals. Furthermore, schizophrenic patients (both with and without TD) showed significantly increased latency for "volitional" saccades compared to the normal controls. These findings may provide further evidence for basal ganglia GABA dysfunction in tardive dyskinesia, as well as demonstrate oculomotor abnormalities in schizophrenic individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 49-59 |
| Number of pages | 11 |
| Journal | Biological Psychiatry |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1989 |
Fingerprint
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Increased saccadic distractibility in tardive dyskinesia : Functional evidence for subcortical GABA dysfunction. / Thaker, G. K.; Nguyen, J. A.; Tamminga, C. A.
In: Biological Psychiatry, Vol. 25, No. 1, 01.01.1989, p. 49-59.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased saccadic distractibility in tardive dyskinesia
T2 - Functional evidence for subcortical GABA dysfunction
AU - Thaker, G. K.
AU - Nguyen, J. A.
AU - Tamminga, C. A.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - In mammals, GABAergic projections from the substantia nigra reticulata to the superior colliculus provide tonic inhibition to tectal neurons involved in the generation of saccades. Dysfunction of this pathway has been shown to produce saccadic "distractibility" in the experimental monkey. In two oculomotor paradigms, control of saccadic eye movements was tested in chronic schizophrenic patients with (n = 18) and without (n = 16) tardive dyskinesia (TD) and normal controls (n = 8). The three groups were matched by mean age; the TD and non-TD patient groups had similar duration of illness, benztropine and chlorpromazine equivalent doses and educational levels. A twofold increase in saccadic distractibility was observed in TD compared to non-TD schizophrenic patients, and both patient groups demonstrated a greater saccadic distractibility than normals. Furthermore, schizophrenic patients (both with and without TD) showed significantly increased latency for "volitional" saccades compared to the normal controls. These findings may provide further evidence for basal ganglia GABA dysfunction in tardive dyskinesia, as well as demonstrate oculomotor abnormalities in schizophrenic individuals.
AB - In mammals, GABAergic projections from the substantia nigra reticulata to the superior colliculus provide tonic inhibition to tectal neurons involved in the generation of saccades. Dysfunction of this pathway has been shown to produce saccadic "distractibility" in the experimental monkey. In two oculomotor paradigms, control of saccadic eye movements was tested in chronic schizophrenic patients with (n = 18) and without (n = 16) tardive dyskinesia (TD) and normal controls (n = 8). The three groups were matched by mean age; the TD and non-TD patient groups had similar duration of illness, benztropine and chlorpromazine equivalent doses and educational levels. A twofold increase in saccadic distractibility was observed in TD compared to non-TD schizophrenic patients, and both patient groups demonstrated a greater saccadic distractibility than normals. Furthermore, schizophrenic patients (both with and without TD) showed significantly increased latency for "volitional" saccades compared to the normal controls. These findings may provide further evidence for basal ganglia GABA dysfunction in tardive dyskinesia, as well as demonstrate oculomotor abnormalities in schizophrenic individuals.
UR - http://www.scopus.com/inward/record.url?scp=0024562006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024562006&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(89)90146-7
DO - 10.1016/0006-3223(89)90146-7
M3 - Article
C2 - 2563231
AN - SCOPUS:0024562006
VL - 25
SP - 49
EP - 59
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -