Increased saccadic distractibility in tardive dyskinesia: Functional evidence for subcortical GABA dysfunction

G. K. Thaker, J. A. Nguyen, C. A. Tamminga

Research output: Contribution to journalArticle

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Abstract

In mammals, GABAergic projections from the substantia nigra reticulata to the superior colliculus provide tonic inhibition to tectal neurons involved in the generation of saccades. Dysfunction of this pathway has been shown to produce saccadic "distractibility" in the experimental monkey. In two oculomotor paradigms, control of saccadic eye movements was tested in chronic schizophrenic patients with (n = 18) and without (n = 16) tardive dyskinesia (TD) and normal controls (n = 8). The three groups were matched by mean age; the TD and non-TD patient groups had similar duration of illness, benztropine and chlorpromazine equivalent doses and educational levels. A twofold increase in saccadic distractibility was observed in TD compared to non-TD schizophrenic patients, and both patient groups demonstrated a greater saccadic distractibility than normals. Furthermore, schizophrenic patients (both with and without TD) showed significantly increased latency for "volitional" saccades compared to the normal controls. These findings may provide further evidence for basal ganglia GABA dysfunction in tardive dyskinesia, as well as demonstrate oculomotor abnormalities in schizophrenic individuals.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalBiological Psychiatry
Volume25
Issue number1
DOIs
StatePublished - Jan 1 1989

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gamma-Aminobutyric Acid
Saccades
Dyskinesias
Benztropine
Superior Colliculi
Chlorpromazine
Basal Ganglia
Haplorhini
Mammals
Research Design
Tardive Dyskinesia
Neurons

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Increased saccadic distractibility in tardive dyskinesia : Functional evidence for subcortical GABA dysfunction. / Thaker, G. K.; Nguyen, J. A.; Tamminga, C. A.

In: Biological Psychiatry, Vol. 25, No. 1, 01.01.1989, p. 49-59.

Research output: Contribution to journalArticle

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abstract = "In mammals, GABAergic projections from the substantia nigra reticulata to the superior colliculus provide tonic inhibition to tectal neurons involved in the generation of saccades. Dysfunction of this pathway has been shown to produce saccadic {"}distractibility{"} in the experimental monkey. In two oculomotor paradigms, control of saccadic eye movements was tested in chronic schizophrenic patients with (n = 18) and without (n = 16) tardive dyskinesia (TD) and normal controls (n = 8). The three groups were matched by mean age; the TD and non-TD patient groups had similar duration of illness, benztropine and chlorpromazine equivalent doses and educational levels. A twofold increase in saccadic distractibility was observed in TD compared to non-TD schizophrenic patients, and both patient groups demonstrated a greater saccadic distractibility than normals. Furthermore, schizophrenic patients (both with and without TD) showed significantly increased latency for {"}volitional{"} saccades compared to the normal controls. These findings may provide further evidence for basal ganglia GABA dysfunction in tardive dyskinesia, as well as demonstrate oculomotor abnormalities in schizophrenic individuals.",
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