Increased sleep time in the offspring of caffeine-treated dams from two inbred strains of mice

C. M. Sinton, J. L. Valatx, M. Jouvet

Research output: Contribution to journalArticle

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Abstract

Dams from two inbred strains of mice (C57BR and BALB/c) were treated with caffeine in solution in their drinking water during gestation. Doses of caffeine used corresponded to about 60, 80 or 100 mg/kg/day; controls received tap water. The offspring (as adults) revealed a significantly increased sleep time following caffeine treatment, but primarily as slow wave sleep in the males of the BALB/c strain and paradoxical sleep in the females of the C57BR strain. BALB/c females and C57BR males were relatively unaffected. These results, and in particular the sex differences, are discussed in terms of a possible central site of action of caffeine.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalNeuroscience Letters
Volume24
Issue number2
DOIs
StatePublished - Jul 2 1981

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Inbred Strains Mice
Caffeine
Sleep
REM Sleep
Sex Characteristics
Drinking Water
Pregnancy
Water
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

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Increased sleep time in the offspring of caffeine-treated dams from two inbred strains of mice. / Sinton, C. M.; Valatx, J. L.; Jouvet, M.

In: Neuroscience Letters, Vol. 24, No. 2, 02.07.1981, p. 169-174.

Research output: Contribution to journalArticle

Sinton, C. M. ; Valatx, J. L. ; Jouvet, M. / Increased sleep time in the offspring of caffeine-treated dams from two inbred strains of mice. In: Neuroscience Letters. 1981 ; Vol. 24, No. 2. pp. 169-174.
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