Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome

Jeffrey H. Pruitt, M. Burress Welborn, Paul D. Edwards, Timothy R S Harward, James W. Seeger, Tomas D. Martin, Christopher Smith, John A. Kenney, Robert I C Wesdorp, Sybren Meijer, Miguel A. Cuesta, Amer Abouhanze, Edward M. Copeland, Judi Giri, John E. Sims, Lyle L. Moldawer, Hester S A Oldenburg

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Plasma interleukin-1 (IL-1) activity is modulated in part through the simultaneous appearance of several inhibitors of IL-1 action, including interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II receptor (IL-1RII). However, little is known concerning the plasma appearance of these inhibitors in patients following operative trauma or those with sepsis syndrome. In the present report, plasma IL-1β, IL-1ra, and soluble IL-1RI arid IL-1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma. Plasma concentrations of IL-1ra increased significantly following elective operative repair of thoraco- abdominal and abdominal aortic aneurysms, and after bowel resection for inflammatory bowel disease, but did not increase after laparoscopic cholecystectomy. Plasma IL-1ra levels were also elevated in patients with sepsis syndrome. In contrast, soluble IL-1RII levels were only increased in patients after operative repair of thoraco-abdominal aortic aneurysms and in sepsis syndrome, whereas concentrations were unaffected by the other more modest surgical procedures. Plasma IL-1RI concentrations decreased in all postoperative patients in the first 24 hours after surgery. We conclude that both plasma IL-1ra and soluble IL-1RII concentrations often increase in sepsis and following some operative trauma. Less severe operative trauma increases the plasma concentration of only IL-1ra, whereas both IL-1ra and soluble IL-1RII are increased in patients with sepsis syndrome or following thoraco-abdominal aneurysm repair.

Original languageEnglish (US)
Pages (from-to)3282-3288
Number of pages7
JournalBlood
Volume87
Issue number8
StatePublished - Apr 15 1996

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Pruitt, J. H., Welborn, M. B., Edwards, P. D., Harward, T. R. S., Seeger, J. W., Martin, T. D., Smith, C., Kenney, J. A., Wesdorp, R. I. C., Meijer, S., Cuesta, M. A., Abouhanze, A., Copeland, E. M., Giri, J., Sims, J. E., Moldawer, L. L., & Oldenburg, H. S. A. (1996). Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. Blood, 87(8), 3282-3288.