Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome

Jeffrey H. Pruitt, M. Burress Welborn, Paul D. Edwards, Timothy R S Harward, James W. Seeger, Tomas D. Martin, Christopher Smith, John A. Kenney, Robert I C Wesdorp, Sybren Meijer, Miguel A. Cuesta, Amer Abouhanze, Edward M. Copeland, Judi Giri, John E. Sims, Lyle L. Moldawer, Hester S A Oldenburg

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Abstract

Plasma interleukin-1 (IL-1) activity is modulated in part through the simultaneous appearance of several inhibitors of IL-1 action, including interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II receptor (IL-1RII). However, little is known concerning the plasma appearance of these inhibitors in patients following operative trauma or those with sepsis syndrome. In the present report, plasma IL-1β, IL-1ra, and soluble IL-1RI arid IL-1RII concentrations were evaluated in 118 patients with sepsis syndrome or after elective operative trauma. Plasma concentrations of IL-1ra increased significantly following elective operative repair of thoraco- abdominal and abdominal aortic aneurysms, and after bowel resection for inflammatory bowel disease, but did not increase after laparoscopic cholecystectomy. Plasma IL-1ra levels were also elevated in patients with sepsis syndrome. In contrast, soluble IL-1RII levels were only increased in patients after operative repair of thoraco-abdominal aortic aneurysms and in sepsis syndrome, whereas concentrations were unaffected by the other more modest surgical procedures. Plasma IL-1RI concentrations decreased in all postoperative patients in the first 24 hours after surgery. We conclude that both plasma IL-1ra and soluble IL-1RII concentrations often increase in sepsis and following some operative trauma. Less severe operative trauma increases the plasma concentration of only IL-1ra, whereas both IL-1ra and soluble IL-1RII are increased in patients with sepsis syndrome or following thoraco-abdominal aneurysm repair.

Original languageEnglish (US)
Pages (from-to)3282-3288
Number of pages7
JournalBlood
Volume87
Issue number8
StatePublished - Apr 15 1996

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Interleukin-1 Type II Receptors
Systemic Inflammatory Response Syndrome
Interleukin-1 Receptors
Plasmas
Interleukin-1
Repair
Abdominal Aortic Aneurysm
Wounds and Injuries
Laparoscopic Cholecystectomy
Inflammatory Bowel Diseases
Surgery
Aneurysm
Sepsis

ASJC Scopus subject areas

  • Hematology

Cite this

Pruitt, J. H., Welborn, M. B., Edwards, P. D., Harward, T. R. S., Seeger, J. W., Martin, T. D., ... Oldenburg, H. S. A. (1996). Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. Blood, 87(8), 3282-3288.

Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. / Pruitt, Jeffrey H.; Welborn, M. Burress; Edwards, Paul D.; Harward, Timothy R S; Seeger, James W.; Martin, Tomas D.; Smith, Christopher; Kenney, John A.; Wesdorp, Robert I C; Meijer, Sybren; Cuesta, Miguel A.; Abouhanze, Amer; Copeland, Edward M.; Giri, Judi; Sims, John E.; Moldawer, Lyle L.; Oldenburg, Hester S A.

In: Blood, Vol. 87, No. 8, 15.04.1996, p. 3282-3288.

Research output: Contribution to journalArticle

Pruitt, JH, Welborn, MB, Edwards, PD, Harward, TRS, Seeger, JW, Martin, TD, Smith, C, Kenney, JA, Wesdorp, RIC, Meijer, S, Cuesta, MA, Abouhanze, A, Copeland, EM, Giri, J, Sims, JE, Moldawer, LL & Oldenburg, HSA 1996, 'Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome', Blood, vol. 87, no. 8, pp. 3282-3288.
Pruitt JH, Welborn MB, Edwards PD, Harward TRS, Seeger JW, Martin TD et al. Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. Blood. 1996 Apr 15;87(8):3282-3288.
Pruitt, Jeffrey H. ; Welborn, M. Burress ; Edwards, Paul D. ; Harward, Timothy R S ; Seeger, James W. ; Martin, Tomas D. ; Smith, Christopher ; Kenney, John A. ; Wesdorp, Robert I C ; Meijer, Sybren ; Cuesta, Miguel A. ; Abouhanze, Amer ; Copeland, Edward M. ; Giri, Judi ; Sims, John E. ; Moldawer, Lyle L. ; Oldenburg, Hester S A. / Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. In: Blood. 1996 ; Vol. 87, No. 8. pp. 3282-3288.
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AU - Abouhanze, Amer

AU - Copeland, Edward M.

AU - Giri, Judi

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