Increased susceptibility to lethal lipopolysaccharide in mice with effects of bacterial b-cell leukemia

M. J. Muirhead, E. S. Vitetta, P. C. Isakson, K. A. Krolick, J. H. Dees, J. W. Uhr

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Susceptibility to the lethal effects of bacterial lipopolysaccharide (LPS) increased more than one hundredfold in BALB/c mice given syngeneic B-cell tumor transplants. The increased susceptibility to LPS that developed during the following weeks paralleled tumor growth in the liver and spleen. The tumor-bearing animals also developed an enhanced capacity to clear colloidal carbon from the blood, consistent with increased activity of the reticuloendothelial system. Although hypersusceptibility to LPS had been reported in a number of animal models, our experiment was the first demonstration in a tumor model that susceptibility correlates with tumor burden.

Original languageEnglish (US)
Pages (from-to)745-753
Number of pages9
JournalJournal of the National Cancer Institute
Volume66
Issue number4
DOIs
StatePublished - Apr 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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