Abstract
Susceptibility to the lethal effects of bacterial lipopolysaccharide (LPS) increased more than one hundredfold in BALB/c mice given syngeneic B-cell tumor transplants. The increased susceptibility to LPS that developed during the following weeks paralleled tumor growth in the liver and spleen. The tumor-bearing animals also developed an enhanced capacity to clear colloidal carbon from the blood, consistent with increased activity of the reticuloendothelial system. Although hypersusceptibility to LPS had been reported in a number of animal models, our experiment was the first demonstration in a tumor model that susceptibility correlates with tumor burden.
Original language | English (US) |
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Pages (from-to) | 745-753 |
Number of pages | 9 |
Journal | Journal of the National Cancer Institute |
Volume | 66 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1981 |
ASJC Scopus subject areas
- Oncology
- Cancer Research