Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism

Aslan T Turer, Gregory D. Lewis, John F. O'Sullivan, Sammy Elmariah, Jessica L. Mega, Tayo A Addo, Marc S. Sabatine, James A de Lemos, Robert E. Gerszten

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To determine whether increases in cardiac work lead to alterations in the plasma metabolome and whether such changes arise from the heart or peripheral organs. Background: There is growing evidence that the heart influences systemic metabolism through endocrine effects and affecting pathways involved in energy homeostasis. Methods: Nineteen patients referred for cardiac catheterization were enrolled. Peripheral and selective coronary sinus (CS) blood sampling was performed at serial timepoints following the initiation of pacing, and metabolite profiling was performed by liquid chromatography-mass spectrometry (LC-MS). Results: Pacing-stress resulted in a 225% increase in the median rate ?pressure product from baseline. Increased myocardial work induced significant changes in the peripheral concentration of 43 of 125 metabolites assayed, including large changes in purine [adenosine (+99%, p = 0.006), ADP (+42%, p = 0.01), AMP (+79%, p = 0.004), GDP (+69%, p = 0.003), GMP (+58%, p = 0.01), IMP (+50%, p = 0.03), xanthine ( +61%, p = 0.0006)], and several bile acid metabolites. The CS changes in metabolites qualitatively mirrored those in the peripheral blood in both timing and magnitude, suggesting the heart was not the major source of the metabolite release. Conclusions: Isolated increases in myocardial work can induce changes in the plasma metabolome, but these changes do not appear to be directly cardiac in origin. A number of these dynamic metabolites have known signaling functions. Our study provides additional evidence to a growing body of literature on metabolic 'cross-talk' between the heart and other organs.

Original languageEnglish (US)
Article numbere99058
JournalPLoS One
Volume9
Issue number6
DOIs
StatePublished - Jun 16 2014

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Metabolites
Workload
Metabolism
metabolites
metabolism
Metabolome
Coronary Sinus
coronary sinus
heart
metabolome
Inosine Monophosphate
Xanthine
Blood
Adenosine Monophosphate
Cardiac Catheterization
Bile Acids and Salts
Liquid Chromatography
Adenosine
Adenosine Diphosphate
Plasmas

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism. / Turer, Aslan T; Lewis, Gregory D.; O'Sullivan, John F.; Elmariah, Sammy; Mega, Jessica L.; Addo, Tayo A; Sabatine, Marc S.; de Lemos, James A; Gerszten, Robert E.

In: PLoS One, Vol. 9, No. 6, e99058, 16.06.2014.

Research output: Contribution to journalArticle

Turer, Aslan T ; Lewis, Gregory D. ; O'Sullivan, John F. ; Elmariah, Sammy ; Mega, Jessica L. ; Addo, Tayo A ; Sabatine, Marc S. ; de Lemos, James A ; Gerszten, Robert E. / Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism. In: PLoS One. 2014 ; Vol. 9, No. 6.
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AU - Mega, Jessica L.

AU - Addo, Tayo A

AU - Sabatine, Marc S.

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