Increasing resistance to trimethoprim-sulfamethoxazole among isolates of escherichia coli in developing countries

Barbara E. Murray, Tito Alvarado, Kyung Hee Kim, Malai Vorachit, Panida Jayanetra, Ingeborg Prenzel, Mary Fling, Lynn Elwell, George H. Mc Cracken, Gilbert Madrigal, Carla Odio, Luis R. Trabulsi

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Resistance of Escherichia coli to trimethoprim (TMP)-sulfamethoxazole remains at 3%8% at many medical centers within the United States. In this study a 44% resistance rate was observed among E. coli isolated at a pediatric hospital in Santiago, Chile, and a 40% resistance rate at a general teaching hospital in Bangkok, Thailand. Most isolates were from urinary tract infections and showed high-level resistance (minimal inhibitory concentration of TMP >1, 000 µg/ml). Nineteen of 35 isolates tested transferred resistance to TMP; most cotransferred resistance to streptomycin and sulfonamides. Dihydrofolate reductase type I was detected by gene probing in 14 of 35 strains. Subsequent investigatio's in Brazil, Honduras, and Costa Rica revealed that this high rate of resistance was not an isolated phenomenon.

Original languageEnglish (US)
Pages (from-to)1107-1113
Number of pages7
JournalJournal of Infectious Diseases
Volume152
Issue number6
DOIs
StatePublished - Dec 1 1985

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Sulfamethoxazole Drug Combination Trimethoprim
Developing Countries
Trimethoprim Resistance
Honduras
Escherichia coli
Costa Rica
Tetrahydrofolate Dehydrogenase
Trimethoprim
Pediatric Hospitals
Chile
Sulfonamides
Streptomycin
Thailand
Urinary Tract Infections
Teaching Hospitals
General Hospitals
Brazil
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Murray, B. E., Alvarado, T., Kim, K. H., Vorachit, M., Jayanetra, P., Prenzel, I., ... Trabulsi, L. R. (1985). Increasing resistance to trimethoprim-sulfamethoxazole among isolates of escherichia coli in developing countries. Journal of Infectious Diseases, 152(6), 1107-1113. https://doi.org/10.1093/infdis/152.6.1107

Increasing resistance to trimethoprim-sulfamethoxazole among isolates of escherichia coli in developing countries. / Murray, Barbara E.; Alvarado, Tito; Kim, Kyung Hee; Vorachit, Malai; Jayanetra, Panida; Prenzel, Ingeborg; Fling, Mary; Elwell, Lynn; Mc Cracken, George H.; Madrigal, Gilbert; Odio, Carla; Trabulsi, Luis R.

In: Journal of Infectious Diseases, Vol. 152, No. 6, 01.12.1985, p. 1107-1113.

Research output: Contribution to journalArticle

Murray, BE, Alvarado, T, Kim, KH, Vorachit, M, Jayanetra, P, Prenzel, I, Fling, M, Elwell, L, Mc Cracken, GH, Madrigal, G, Odio, C & Trabulsi, LR 1985, 'Increasing resistance to trimethoprim-sulfamethoxazole among isolates of escherichia coli in developing countries', Journal of Infectious Diseases, vol. 152, no. 6, pp. 1107-1113. https://doi.org/10.1093/infdis/152.6.1107
Murray, Barbara E. ; Alvarado, Tito ; Kim, Kyung Hee ; Vorachit, Malai ; Jayanetra, Panida ; Prenzel, Ingeborg ; Fling, Mary ; Elwell, Lynn ; Mc Cracken, George H. ; Madrigal, Gilbert ; Odio, Carla ; Trabulsi, Luis R. / Increasing resistance to trimethoprim-sulfamethoxazole among isolates of escherichia coli in developing countries. In: Journal of Infectious Diseases. 1985 ; Vol. 152, No. 6. pp. 1107-1113.
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