Independently measured oxygen consumption during reduction of oxygen delivery by positive end-expiratory pressure

P. E. Pepe, B. H. Culver

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Oxygen consumption (V̇O2) is often assumed to be fixed by metabolic demand, but some investigations have found V̇O2 linearly dependent on O2 delivery (Q̇·CaO2) during positive end-expiratory pressure (PEEP) trials for the adult respiratory distress syndrome. However, in those studies V̇O2 was calculated using the same cardiac output (Q̇T) and O2 content measurements used to calculate the O2 delivery to which it was being compared. We therefore obtained independent measurements of V̇O2, Q̇T, and oxygen contents under 3 conditions in 21 dogs: 14 normal dogs, each receiving varying degrees of PEEP or central venous obstruction, and 7 dogs receiving PEEP after developing pulmonary edema from intravenously infused oleic acid. In all groups, V̇O2 measured from expired gas analysis remained unchanged until Q̇T·CaO2 was reduced to below 13 ml/kg/min. The V̇O2 was then linearly dependent on Q̇T·CaO2. We conclude that this reduction in V̇O2 is due to severe Q̇T·CaO2 reduction and not to any special effect of PEEP or lung injury.

Original languageEnglish (US)
Pages (from-to)788-792
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume132
Issue number4
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Independently measured oxygen consumption during reduction of oxygen delivery by positive end-expiratory pressure'. Together they form a unique fingerprint.

  • Cite this