Abstract
• Indinavir is a well-known cause of crystal-induced acute renal failure, dysuria and flank pain, and nephrolithiasis. Recently a more insidious tubulointerstitial lesion has been recognized as secondary to the drug. We report a case of a hepatitis C-positive patient on long-term indinavir therapy for human immunodeficiency virus (HIV) who developed a slowly progressive rise in serum creatinine. Renal biopsy revealed a diffuse interstitial infiltrate with numerous eosinophils and scarring. The tubules showed focal necrosis and dilation with elongated crystals present within their lumina. The elevated serum creatinine decreased to a new baseline over several months with the discontinuation of indinavir. We review the literature of renal syndromes associated with indinavir focusing on chronic progressive tubulointerstitial injury and speculate on risk factors and potential mechanisms of indinavir-induced renal injury.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Kidney Diseases |
| Volume | 38 |
| Issue number | 4 SUPPL. 3 |
| DOIs | |
| State | Published - Oct 2001 |
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Keywords
- Crystals
- Human immunodeficiency virus (HIV)
- Hypertension
- Indinavir
- Pyuria
- Renal failure
ASJC Scopus subject areas
- Nephrology
Cite this
Indinavir Nephropathy Revisited : A Pattern of Insidious Renal Failure with Identifiable Risk Factors. / Reilly, Robert F.; Tray, Kory; Perazella, Mark A.
In: American Journal of Kidney Diseases, Vol. 38, No. 4 SUPPL. 3, 10.2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Indinavir Nephropathy Revisited
T2 - A Pattern of Insidious Renal Failure with Identifiable Risk Factors
AU - Reilly, Robert F.
AU - Tray, Kory
AU - Perazella, Mark A.
PY - 2001/10
Y1 - 2001/10
N2 - • Indinavir is a well-known cause of crystal-induced acute renal failure, dysuria and flank pain, and nephrolithiasis. Recently a more insidious tubulointerstitial lesion has been recognized as secondary to the drug. We report a case of a hepatitis C-positive patient on long-term indinavir therapy for human immunodeficiency virus (HIV) who developed a slowly progressive rise in serum creatinine. Renal biopsy revealed a diffuse interstitial infiltrate with numerous eosinophils and scarring. The tubules showed focal necrosis and dilation with elongated crystals present within their lumina. The elevated serum creatinine decreased to a new baseline over several months with the discontinuation of indinavir. We review the literature of renal syndromes associated with indinavir focusing on chronic progressive tubulointerstitial injury and speculate on risk factors and potential mechanisms of indinavir-induced renal injury.
AB - • Indinavir is a well-known cause of crystal-induced acute renal failure, dysuria and flank pain, and nephrolithiasis. Recently a more insidious tubulointerstitial lesion has been recognized as secondary to the drug. We report a case of a hepatitis C-positive patient on long-term indinavir therapy for human immunodeficiency virus (HIV) who developed a slowly progressive rise in serum creatinine. Renal biopsy revealed a diffuse interstitial infiltrate with numerous eosinophils and scarring. The tubules showed focal necrosis and dilation with elongated crystals present within their lumina. The elevated serum creatinine decreased to a new baseline over several months with the discontinuation of indinavir. We review the literature of renal syndromes associated with indinavir focusing on chronic progressive tubulointerstitial injury and speculate on risk factors and potential mechanisms of indinavir-induced renal injury.
KW - Crystals
KW - Human immunodeficiency virus (HIV)
KW - Hypertension
KW - Indinavir
KW - Pyuria
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=0347081593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347081593&partnerID=8YFLogxK
U2 - 10.1053/ajkd.2001.27732
DO - 10.1053/ajkd.2001.27732
M3 - Article
C2 - 11576910
AN - SCOPUS:0347081593
VL - 38
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 4 SUPPL. 3
ER -