Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations

Mitzi M. Gonzales, Takashi Tarumi, Danielle E. Eagan, Hirofumi Tanaka, Miral Vaghasia, Andreana P. Haley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

OBJECTIVE: Elevated body mass index (BMI) at midlife is associated with increased risk of cognitive decline in later life. The goal of the current study was to assess mechanisms of early brain vulnerability by examining if higher BMI at midlife affects current cognitive performance through alterations in cerebral neurochemistry. METHODS: Fifty-five participants, aged 40 to 60 years, underwent neuropsychological testing, health screen, and proton magnetic resonance spectroscopy examining N-acetylaspartate, creatine (Cr), myo-inositol (mI), choline, and glutamate concentrations in occipitoparietal gray matter. Concentrations of N-acetylaspartate, choline, mI, and glutamate were calculated as a ratio over Cr and examined in relation to BMI using multivariate regression analyses. Structural equation modeling was used to determine if BMI had an indirect effect on cognition through cerebral metabolite levels. RESULTS: Higher BMI was associated with elevations in mI/Cr (F(5,45) = 3.843, p =.006, β = 0.444, p =.002), independent of age, sex, fasting glucose levels, and systolic blood pressure. Moreover, a χ difference test of the direct and indirect structural equation models revealed that BMI had an indirect effect on global cognitive performance (Δχ = 19.939, df = 2, p <.001). Subsequent follow-up analyses revealed that this effect was specific to memory (Δχ = 22.027, df = 2, p <.001). CONCLUSIONS: Higher BMI was associated with elevations in mI/Cr concentrations in the occipitoparietal gray matter and indirectly related to poorer memory performance through mI/Cr levels, potentially implicating plasma hypertonicity and neuroinflammation as mechanisms underlying obesity-related brain vulnerability.

Original languageEnglish (US)
Pages (from-to)691-698
Number of pages8
JournalPsychosomatic Medicine
Volume74
Issue number7
DOIs
StatePublished - Sep 1 2012

Fingerprint

Creatine
Body Mass Index
Inositol
Choline
Glutamic Acid
Blood Pressure
Neurochemistry
Structural Models
Brain
Cognition
Fasting
Multivariate Analysis
Obesity
Regression Analysis
Glucose
Health
Gray Matter
N-acetylaspartate
Elevation
Grey Matter

Keywords

  • BMI
  • myo-inositol
  • obesity
  • proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations. / Gonzales, Mitzi M.; Tarumi, Takashi; Eagan, Danielle E.; Tanaka, Hirofumi; Vaghasia, Miral; Haley, Andreana P.

In: Psychosomatic Medicine, Vol. 74, No. 7, 01.09.2012, p. 691-698.

Research output: Contribution to journalArticle

Gonzales, Mitzi M. ; Tarumi, Takashi ; Eagan, Danielle E. ; Tanaka, Hirofumi ; Vaghasia, Miral ; Haley, Andreana P. / Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations. In: Psychosomatic Medicine. 2012 ; Vol. 74, No. 7. pp. 691-698.
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AB - OBJECTIVE: Elevated body mass index (BMI) at midlife is associated with increased risk of cognitive decline in later life. The goal of the current study was to assess mechanisms of early brain vulnerability by examining if higher BMI at midlife affects current cognitive performance through alterations in cerebral neurochemistry. METHODS: Fifty-five participants, aged 40 to 60 years, underwent neuropsychological testing, health screen, and proton magnetic resonance spectroscopy examining N-acetylaspartate, creatine (Cr), myo-inositol (mI), choline, and glutamate concentrations in occipitoparietal gray matter. Concentrations of N-acetylaspartate, choline, mI, and glutamate were calculated as a ratio over Cr and examined in relation to BMI using multivariate regression analyses. Structural equation modeling was used to determine if BMI had an indirect effect on cognition through cerebral metabolite levels. RESULTS: Higher BMI was associated with elevations in mI/Cr (F(5,45) = 3.843, p =.006, β = 0.444, p =.002), independent of age, sex, fasting glucose levels, and systolic blood pressure. Moreover, a χ difference test of the direct and indirect structural equation models revealed that BMI had an indirect effect on global cognitive performance (Δχ = 19.939, df = 2, p <.001). Subsequent follow-up analyses revealed that this effect was specific to memory (Δχ = 22.027, df = 2, p <.001). CONCLUSIONS: Higher BMI was associated with elevations in mI/Cr concentrations in the occipitoparietal gray matter and indirectly related to poorer memory performance through mI/Cr levels, potentially implicating plasma hypertonicity and neuroinflammation as mechanisms underlying obesity-related brain vulnerability.

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