Individual differences in cancer susceptibility

C. C. Harris, J. J. Mulvihill, S. S. Thorgeirsson, J. D. Minna

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The major determinants of cancer risk are environmental carcinogens and predisposing host factors. Interactions between these determinants are now being studied by clinical-laboratory investigations. An individual may be predisposed to cancer by both genetic and acquired conditions. Genes related to malignancy and to carcinogensis have been mapped to individual chromosomes in several species, including humans. Because most environmental chemical carcinogens require enzymatic activitation and a wide variation in carcinogen metabolism among people has been found, the ratio of metabolic activation to deactivation of carcinogens may ascertain, in part, a person's cancer risk. Additionally, cancer risk of chemical and physical agents can be qualitatively predicted by carcinogenicity tests in experimental animals. The merging field of cancer ecogenetics is aiding efforts to prevent human cancer.

Original languageEnglish (US)
Pages (from-to)809-825
Number of pages17
JournalAnnals of Internal Medicine
Volume92
Issue number6
StatePublished - 1980

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Individuality
Neoplasms
Environmental Carcinogens
Carcinogens
Carcinogenicity Tests
Causality
Chromosomes
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Harris, C. C., Mulvihill, J. J., Thorgeirsson, S. S., & Minna, J. D. (1980). Individual differences in cancer susceptibility. Annals of Internal Medicine, 92(6), 809-825.

Individual differences in cancer susceptibility. / Harris, C. C.; Mulvihill, J. J.; Thorgeirsson, S. S.; Minna, J. D.

In: Annals of Internal Medicine, Vol. 92, No. 6, 1980, p. 809-825.

Research output: Contribution to journalArticle

Harris, CC, Mulvihill, JJ, Thorgeirsson, SS & Minna, JD 1980, 'Individual differences in cancer susceptibility', Annals of Internal Medicine, vol. 92, no. 6, pp. 809-825.
Harris CC, Mulvihill JJ, Thorgeirsson SS, Minna JD. Individual differences in cancer susceptibility. Annals of Internal Medicine. 1980;92(6):809-825.
Harris, C. C. ; Mulvihill, J. J. ; Thorgeirsson, S. S. ; Minna, J. D. / Individual differences in cancer susceptibility. In: Annals of Internal Medicine. 1980 ; Vol. 92, No. 6. pp. 809-825.
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